Taking Fingerprints of DNA Polymerases : Multiplex Enzyme Profiling on DNA Arrays


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KRANASTER, Ramon, Andreas MARX, 2009. Taking Fingerprints of DNA Polymerases : Multiplex Enzyme Profiling on DNA Arrays. In: Angewandte Chemie : Internat. Ed.. 48(25), pp. 4625-4628. ISSN 1433-7851. eISSN 1521-3773

@article{Kranaster2009Takin-9804, title={Taking Fingerprints of DNA Polymerases : Multiplex Enzyme Profiling on DNA Arrays}, year={2009}, doi={10.1002/anie.200900953}, number={25}, volume={48}, issn={1433-7851}, journal={Angewandte Chemie : Internat. Ed.}, pages={4625--4628}, author={Kranaster, Ramon and Marx, Andreas} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/9804"> <dcterms:bibliographicCitation>First publ. in: Angewandte Chemie : Internat. Ed. ; 48 (2009), 25. - S. 4625-4628</dcterms:bibliographicCitation> <dcterms:abstract xml:lang="eng">DNA polymerases are used in a plethora of biotechnical applications, especially in the polymerase chain reaction (PCR), genetic cloning procedures, genome sequencing, and diagnostic methods.[1] Highly processive and accurate DNA polymerases are desired for cloning procedures in order to give shorter extension times as well as more robust and highyield amplification. A higher DNA polymerase fidelity may increase the reliability of genome sequencing and diagnostic systems.[2] Amplification of ancient DNA samples requires DNA polymerases with an increased substrate spectrum to efficiently overcome typical DNA lesions.[3] To enhance the efficiency of forensic DNA testing, DNA polymerases resistant to inhibitors from blood and soil allow PCR without prior DNA purification.[4] Further improvements of DNA polymerases are required, for example, to meet the requirements of real-time DNA single-molecule sequencing, which relies on the ability ofDNApolymerases to efficiently process modified nucleotides.[5] Overall, customized and artificially engineered DNA polymerases that lead to more robust and specific reaction systems are urgently needed.</dcterms:abstract> <dcterms:title>Taking Fingerprints of DNA Polymerases : Multiplex Enzyme Profiling on DNA Arrays</dcterms:title> <dc:contributor>Marx, Andreas</dc:contributor> <dc:contributor>Kranaster, Ramon</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:14:31Z</dc:date> <dc:format>application/pdf</dc:format> <dc:rights>deposit-license</dc:rights> <dc:creator>Marx, Andreas</dc:creator> <dcterms:issued>2009</dcterms:issued> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/9804"/> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:creator>Kranaster, Ramon</dc:creator> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>

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