Two-stage dynamic DNA quality check by Xeroderma Pigmentosum group C protein


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CAMENISCH, Ulrike, Daniel TRÄUTLEIN, Flurina C. CLEMENT, Jia FEI, Alfred LEITENSTORFER, Elisa MAY, Hanspeter NAEGELI, 2009. Two-stage dynamic DNA quality check by Xeroderma Pigmentosum group C protein. In: The EMBO Journal. 28(16), pp. 2387-2399. ISSN 0261-4189. eISSN 1460-2075. Available under: doi: 10.1038/emboj.2009.187

@article{Camenisch2009Twost-979, title={Two-stage dynamic DNA quality check by Xeroderma Pigmentosum group C protein}, year={2009}, doi={10.1038/emboj.2009.187}, number={16}, volume={28}, issn={0261-4189}, journal={The EMBO Journal}, pages={2387--2399}, author={Camenisch, Ulrike and Träutlein, Daniel and Clement, Flurina C. and Fei, Jia and Leitenstorfer, Alfred and May, Elisa and Naegeli, Hanspeter} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:creator>May, Elisa</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>May, Elisa</dc:contributor> <dcterms:issued>2009</dcterms:issued> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Camenisch, Ulrike</dc:contributor> <dcterms:rights rdf:resource=""/> <dc:creator>Fei, Jia</dc:creator> <bibo:uri rdf:resource=""/> <dcterms:available rdf:datatype="">2011-03-22T17:52:36Z</dcterms:available> <dc:contributor>Träutlein, Daniel</dc:contributor> <dc:contributor>Naegeli, Hanspeter</dc:contributor> <dcterms:abstract xml:lang="eng">Xeroderma pigmentosum group C (XPC) protein initiates the DNA excision repair of helix-distorting base lesions. To understand how this versatile subunit searches for aberrant sites within the vast background of normal genomic DNA, the real-time redistribution of fluorescent fusion constructs was monitored after high-resolution DNA damage induction. Bidirectional truncation analyses disclosed a surprisingly short recognition hotspot, comprising approx15% of human XPC, that includes two beta-hairpin domains with a preference for non-hydrogen-bonded bases in double-stranded DNA. However, to detect damaged sites in living cells, these DNA-attractive domains depend on the partially DNA-repulsive action of an adjacent beta-turn extension that promotes the mobility of XPC molecules searching for lesions. The key function of this dynamic interaction surface is shown by a site-directed charge inversion, which results in increased affinity for native DNA, retarded nuclear mobility and diminished repair efficiency. These studies reveal a two-stage discrimination process, whereby XPC protein first deploys a dynamic sensor interface to rapidly interrogate the double helix, thus forming a transient recognition intermediate before the final installation of a more static repair-initiating complex.</dcterms:abstract> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Clement, Flurina C.</dc:contributor> <dcterms:isPartOf rdf:resource=""/> <dcterms:bibliographicCitation>First publ. in: The EMBO Journal ; 28 (2009), 16. - pp. 2387-2399</dcterms:bibliographicCitation> <dcterms:title>Two-stage dynamic DNA quality check by Xeroderma Pigmentosum group C protein</dcterms:title> <dspace:isPartOfCollection rdf:resource=""/> <dc:creator>Clement, Flurina C.</dc:creator> <dc:creator>Naegeli, Hanspeter</dc:creator> <dc:contributor>Leitenstorfer, Alfred</dc:contributor> <dc:creator>Träutlein, Daniel</dc:creator> <dcterms:hasPart rdf:resource=""/> <dspace:hasBitstream rdf:resource=""/> <dc:creator>Camenisch, Ulrike</dc:creator> <dc:date rdf:datatype="">2011-03-22T17:52:36Z</dc:date> <dc:contributor>Fei, Jia</dc:contributor> <dc:creator>Leitenstorfer, Alfred</dc:creator> <dspace:isPartOfCollection rdf:resource=""/> <dcterms:isPartOf rdf:resource=""/> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>

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