KOPS - The Institutional Repository of the University of Konstanz

Temporary attachment of carbohydrates to cyclopeptide templates : a new strategy for single-bead analysis of multivalent neoglycopeptides

Temporary attachment of carbohydrates to cyclopeptide templates : a new strategy for single-bead analysis of multivalent neoglycopeptides

Cite This

Files in this item

Checksum: MD5:31231dff8265dfe8c0d7616ced0d0cbc

WITTMANN, Valentin, Sonja SEEBERGER, Hermann SCHÄGGER, 2003. Temporary attachment of carbohydrates to cyclopeptide templates : a new strategy for single-bead analysis of multivalent neoglycopeptides. In: Tetrahedron Letters. 44(52), pp. 9243-9246. ISSN 0040-4039. Available under: doi: 10.1016/j.tetlet.2003.10.078

@article{Wittmann2003Tempo-9750, title={Temporary attachment of carbohydrates to cyclopeptide templates : a new strategy for single-bead analysis of multivalent neoglycopeptides}, year={2003}, doi={10.1016/j.tetlet.2003.10.078}, number={52}, volume={44}, issn={0040-4039}, journal={Tetrahedron Letters}, pages={9243--9246}, author={Wittmann, Valentin and Seeberger, Sonja and Schägger, Hermann} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/9750"> <dc:creator>Schägger, Hermann</dc:creator> <dc:rights>terms-of-use</dc:rights> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/9750/1/Temporary_attachment_of_carbohydrates_to_cyclopeptide_templates.pdf"/> <dcterms:title>Temporary attachment of carbohydrates to cyclopeptide templates : a new strategy for single-bead analysis of multivalent neoglycopeptides</dcterms:title> <dc:contributor>Wittmann, Valentin</dc:contributor> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:contributor>Seeberger, Sonja</dc:contributor> <dc:format>application/pdf</dc:format> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:14:09Z</dcterms:available> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:14:09Z</dc:date> <dcterms:bibliographicCitation>First publ. in: Tetrahedron Letters 44 (2003), 52, pp. 9243-9246</dcterms:bibliographicCitation> <dc:creator>Wittmann, Valentin</dc:creator> <dc:creator>Seeberger, Sonja</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Schägger, Hermann</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/9750/1/Temporary_attachment_of_carbohydrates_to_cyclopeptide_templates.pdf"/> <dcterms:abstract xml:lang="eng">Employing a cleavable carbohydrate peptide linker, a new strategy for single-bead analysis of multivalent cyclic neoglycopeptides based on Edman degradation is described. Edman degradation of glycopeptides is hampered by the acid lability of the glycosidic bond and potential incompatibilities of phenylthiohydantoin (PTH) derivatives of glycosylated amino acids with PTH derivatives of the proteinogenic amino acids. To overcome this problem, carbohydrates are detached from the cyclopeptide templates before single-bead analysis, allowing for micro sequencing under routine conditions. With this strategy, application of multivalent cyclic neoglycopeptides in split-mix libraries with a subsequent screening process becomes possible for the first time.</dcterms:abstract> <dcterms:issued>2003</dcterms:issued> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dc:language>eng</dc:language> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/9750"/> </rdf:Description> </rdf:RDF>

Downloads since Oct 1, 2014 (Information about access statistics)

Temporary_attachment_of_carbohydrates_to_cyclopeptide_templates.pdf 225

This item appears in the following Collection(s)

terms-of-use Except where otherwise noted, this item's license is described as terms-of-use

Search KOPS


Browse

My Account