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Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates : a Combinatorial Approach

Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates : a Combinatorial Approach

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SEEBERGER, Sonja, Valentin WITTMANN, 2001. Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates : a Combinatorial Approach. In: EPTON, Roger, ed.. Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries 2000. Kingswinford:Mayflower, pp. 355-358

@incollection{Seeberger2001Cycli-9725, title={Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates : a Combinatorial Approach}, year={2001}, address={Kingswinford}, publisher={Mayflower}, booktitle={Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries 2000}, pages={355--358}, editor={Epton, Roger}, author={Seeberger, Sonja and Wittmann, Valentin} }

application/pdf eng 2011-03-24T18:13:58Z 2011-03-24T18:13:58Z deposit-license Wittmann, Valentin First publ. in: Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries 2000 / ed. Roger Epton. Kingswinford: Mayflower 2001, pp. 355-358 Seeberger, Sonja 2001 Wittmann, Valentin Cyclic Peptides as Scaffolds for Multivalent Presentation of Carbohydrates : a Combinatorial Approach Seeberger, Sonja Carbohydrate lectin interactions mediate a large variety of intercellular recognition events. Since the interactions of individual saccharide groups are usually of low affinity and broad specificity, subsite and subunit multivalency is often employed by nature in order to enhance the attractive binding forces. Accordingly, the synthesis of multivalent carbohydrate ligands has recently attracted interest. Binding studies with these multivalent ligands revealed the importance of the spacer between the monomeric epitopes. Attachment of the saccharides to rigid scaffolds can result in particularly pronounced affinity enhancements provided that the sugars are presented in the correct spatial arrangement. However, in contrast to the utilization of flexible linkers, a larger number of ligands has to be screened in order to find a ligand with the<br />appropriate orientation of the carbohydrates.<br />Here we present a synthetic approach that enables the preparation of libraries of conformationally restricted cyclic peptides which can serve as scaffolds for the multivalent presentation of carbohydrate ligands [3]. Such libraries are useful to identify high affinity lectin ligands based on multivalent interactions and to determine the required orientation of the carbohydrates via conformational analysis of the cyclopeptide scaffold.

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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