Luteinizing hormone-releasing hormone antagonists

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MEZÖ, Gábor, Marilena MANEA, 2009. Luteinizing hormone-releasing hormone antagonists. In: Expert Opinion On Therapeutics Patents. 19(12), pp. 1771-1785. ISSN 1354-3776. eISSN 1744-7674. Available under: doi: 10.1517/13543770903410237

@article{Mezo2009Lutei-9668, title={Luteinizing hormone-releasing hormone antagonists}, year={2009}, doi={10.1517/13543770903410237}, number={12}, volume={19}, issn={1354-3776}, journal={Expert Opinion On Therapeutics Patents}, pages={1771--1785}, author={Mezö, Gábor and Manea, Marilena} }

Mezö, Gábor eng Luteinizing hormone-releasing hormone antagonists 2011-03-24T18:13:34Z deposit-license 2009 Manea, Marilena Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH receptors expressed on cancer cells, LH-RH agonists and antagonists have been developed for different therapeutic applications.<br />Objective/method: Here we give an overview of the most relevant LH-RH antagonists and their therapeutic applications. Recently patented compounds as well as drug formulations and dosage are presented.<br />Conclusion: LH-RH antagonists have found clinical applications in in vitro fertilization, benign prostatic hyperplasia, endometriosis and in the treatment of hormone-dependent tumors. Work in progress is focused on further development of both peptidic and orally active non-peptidic LH-RH antagonists. Manea, Marilena First publ. in: Expert Opinion On Therapeutics Patents ; 19 (2009), 12. - S. 1771-1785 application/pdf Mezö, Gábor

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