Cobalt mediated intramolecular [2+2+2]-cycloaddition of enediynes towards linear annelated polycycles
| Type of Publication: | Journal article |
| URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-46297 |
| Author: | Eckenberg, Peter; Groth, Ulrich |
| Year of publication: | 2003 |
| Published in: | Synlett ; 23 (2003), 14. - pp. 2188-2192. - ISSN 0570-0833. - eISSN 1521-3773 |
| DOI (citable link): | https://dx.doi.org/10.1002/anie.198405393 |
| Summary: |
The cobalt mediated [2+2+2]-cycloaddition of enediynes 13 and 18 affords linear annelated polycycles such as the hexahydro naphthalene 14 and the decahydro anthracene 19. This latter compound can be transformed into the enantiomerically pure anthracene derivative 21 in only two reaction steps. 1,9,10-Trihydroxy octahydro anthracene (21) represents the ABC-framework of many anthracycline antibiotics such as the antitumor active daunomycine.
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| Subject (DDC): | 540 Chemistry |
| Keywords: | [2+2+2]-cycloaddition, enediynes, annelated polycycles |
| Link to License: | Attribution-NonCommercial-NoDerivs 2.0 Generic |
| Bibliography of Konstanz: | Yes |
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ECKENBERG, Peter, Ulrich GROTH, 2003. Cobalt mediated intramolecular [2+2+2]-cycloaddition of enediynes towards linear annelated polycycles. In: Synlett. 23(14), pp. 2188-2192. ISSN 0570-0833. eISSN 1521-3773. Available under: doi: 10.1002/anie.198405393
@article{Eckenberg2003Cobal-9632, title={Cobalt mediated intramolecular [2+2+2]-cycloaddition of enediynes towards linear annelated polycycles}, year={2003}, doi={10.1002/anie.198405393}, number={14}, volume={23}, issn={0570-0833}, journal={Synlett}, pages={2188--2192}, author={Eckenberg, Peter and Groth, Ulrich} }
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