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Post-translational Tyrosine Nitration of Eosinophil Granule Toxins Mediated by Eosinophil Peroxidase

Post-translational Tyrosine Nitration of Eosinophil Granule Toxins Mediated by Eosinophil Peroxidase

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ULRICH, Martina, Brînduşa-Alina PETRE, Nikolay YOUHNOVSKI, Franziska PRÖMM, Markus SCHIRLE, Michael SCHUMM, Ralph S. PERO, Alfred DOYLE, James CHECKEL, Hirohito KITA, Nethaji THIYAGARAJAN, K. Ravi ACHARYA, Peter SCHMID-GRENDELMEIER, Hans-Uwe SIMON, Heinz SCHWARZ, Masato TSUTSUI, Hiroaki SHIMOKAWA, Gabriel BELLON, James J. LEE, Michael PRZYBYLSKI, Gerd DÖRING, 2008. Post-translational Tyrosine Nitration of Eosinophil Granule Toxins Mediated by Eosinophil Peroxidase. In: Journal of Biological Chemistry. 283(42), pp. 28629-28640. ISSN 0021-9258. eISSN 1083-351X. Available under: doi: 10.1074/jbc.M801196200

@article{Ulrich2008Postt-9609, title={Post-translational Tyrosine Nitration of Eosinophil Granule Toxins Mediated by Eosinophil Peroxidase}, year={2008}, doi={10.1074/jbc.M801196200}, number={42}, volume={283}, issn={0021-9258}, journal={Journal of Biological Chemistry}, pages={28629--28640}, author={Ulrich, Martina and Petre, Brînduşa-Alina and Youhnovski, Nikolay and Prömm, Franziska and Schirle, Markus and Schumm, Michael and Pero, Ralph S. and Doyle, Alfred and Checkel, James and Kita, Hirohito and Thiyagarajan, Nethaji and Acharya, K. Ravi and Schmid-Grendelmeier, Peter and Simon, Hans-Uwe and Schwarz, Heinz and Tsutsui, Masato and Shimokawa, Hiroaki and Bellon, Gabriel and Lee, James J. and Przybylski, Michael and Döring, Gerd} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/9609"> <dc:contributor>Youhnovski, Nikolay</dc:contributor> <dc:contributor>Lee, James J.</dc:contributor> <dc:contributor>Pero, Ralph S.</dc:contributor> <dc:contributor>Checkel, James</dc:contributor> <dc:creator>Thiyagarajan, Nethaji</dc:creator> <dc:creator>Schwarz, Heinz</dc:creator> <dc:contributor>Schwarz, Heinz</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dc:creator>Schmid-Grendelmeier, Peter</dc:creator> <dc:language>eng</dc:language> <dc:contributor>Schirle, Markus</dc:contributor> <dc:contributor>Ulrich, Martina</dc:contributor> <dc:creator>Simon, Hans-Uwe</dc:creator> <dc:contributor>Schumm, Michael</dc:contributor> <dc:contributor>Bellon, Gabriel</dc:contributor> <dc:creator>Schirle, Markus</dc:creator> <dc:contributor>Kita, Hirohito</dc:contributor> <dc:creator>Shimokawa, Hiroaki</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/9609/1/JBC_2008_UlrichPetre.pdf"/> <dc:format>application/pdf</dc:format> <dc:creator>Checkel, James</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:13:08Z</dcterms:available> <dc:rights>deposit-license</dc:rights> <dc:contributor>Simon, Hans-Uwe</dc:contributor> <dc:contributor>Petre, Brînduşa-Alina</dc:contributor> <dc:contributor>Doyle, Alfred</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:13:08Z</dc:date> <dc:contributor>Tsutsui, Masato</dc:contributor> <dc:contributor>Shimokawa, Hiroaki</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Döring, Gerd</dc:creator> <dc:contributor>Döring, Gerd</dc:contributor> <dc:creator>Ulrich, Martina</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/9609/1/JBC_2008_UlrichPetre.pdf"/> <dc:creator>Przybylski, Michael</dc:creator> <dc:contributor>Thiyagarajan, Nethaji</dc:contributor> <dc:creator>Lee, James J.</dc:creator> <dc:creator>Youhnovski, Nikolay</dc:creator> <dc:contributor>Acharya, K. Ravi</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dcterms:bibliographicCitation>First publ. in: Journal of Biological Chemistry 283 (2008), 42, pp. 28629-28640</dcterms:bibliographicCitation> <dc:creator>Pero, Ralph S.</dc:creator> <dc:contributor>Prömm, Franziska</dc:contributor> <dcterms:issued>2008</dcterms:issued> <dc:creator>Tsutsui, Masato</dc:creator> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:contributor>Schmid-Grendelmeier, Peter</dc:contributor> <dc:creator>Acharya, K. Ravi</dc:creator> <dc:creator>Bellon, Gabriel</dc:creator> <dc:creator>Schumm, Michael</dc:creator> <dc:creator>Doyle, Alfred</dc:creator> <dc:creator>Prömm, Franziska</dc:creator> <dcterms:abstract xml:lang="eng">Nitration of tyrosine residues has been observed during various acute and chronic inflammatory diseases. However, the mechanism of tyrosine nitration and the nature of the proteins that become tyrosine nitrated during inflammation remain unclear. Here we show that eosinophils but not other cell types including neutrophils contain nitrotyrosine-positive proteins in specific granules. Furthermore, we demonstrate that the human eosinophil toxins, eosinophil peroxidase (EPO), major basic protein, eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP), and the respective murine toxins, are post-translationally modified by nitration at tyrosine residues during cell maturation. High resolution affinity-mass spectrometry identified specific single nitration sites at Tyr349 in EPO and Tyr33 in both ECP and EDN. ECP and EDN crystal structures revealed and EPO structure modeling suggested that the nitrated tyrosine residues in the toxins are surface exposed. Studies in EPO-/-, gp91phox-/-, and NOS-/- mice revealed that tyrosine nitration of these toxins is mediated by EPO in the presence of hydrogen peroxide and minute amounts of NOx. Tyrosine nitration of eosinophil granule toxins occurs during maturation of eosinophils, independent of inflammation. These results provide evidence that post-translational tyrosine nitration is unique to eosinophils.</dcterms:abstract> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Przybylski, Michael</dc:contributor> <dcterms:title>Post-translational Tyrosine Nitration of Eosinophil Granule Toxins Mediated by Eosinophil Peroxidase</dcterms:title> <dc:creator>Kita, Hirohito</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/9609"/> <dc:creator>Petre, Brînduşa-Alina</dc:creator> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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