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Molecular Insights into Error-Prone DNA Replication and Error-Free Lesion Bypass

Molecular Insights into Error-Prone DNA Replication and Error-Free Lesion Bypass

Type of Publication: Journal article
URI (citable link): http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-128200
Author: Marx, Andreas; Summerer, Daniel
Year of publication: 2002
Published in: ChemBioChem ; 3 (2002), 5. - pp. 405-407. - ISSN 1439-4227. - eISSN 1439-7633
DOI (citable link): https://dx.doi.org/10.1002/1439-7633(20020503)3:5<405::AID-CBIC405>3.0.CO;2-4
Summary:
New DNA polymerase structures that differ significantly from known high-fidelity DNA polymerases provide new insights into how polymerases bypass damaged DNA like 1. Crystal structures of several Y-family DNA polymerases have recently been solved (see right-hand picture) and suggest that more open active sites may be the reason for the error propensity of low-fidelity polymerases.
Subject (DDC): 540 Chemistry
Keywords: DNA damage, DNA polymerases, DNA replication, thymidine dimers, UV light
Link to License: In Copyright

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MARX, Andreas, Daniel SUMMERER, 2002. Molecular Insights into Error-Prone DNA Replication and Error-Free Lesion Bypass. In: ChemBioChem. 3(5), pp. 405-407. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/1439-7633(20020503)3:5<405::AID-CBIC405>3.0.CO;2-4

@article{Marx2002Molec-9607, title={Molecular Insights into Error-Prone DNA Replication and Error-Free Lesion Bypass}, year={2002}, doi={10.1002/1439-7633(20020503)3:5<405::AID-CBIC405>3.0.CO;2-4}, number={5}, volume={3}, issn={1439-4227}, journal={ChemBioChem}, pages={405--407}, author={Marx, Andreas and Summerer, Daniel} }

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