Molecular Insights into Error-Prone DNA Replication and Error-Free Lesion Bypass
| Type of Publication: | Journal article |
| URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-128200 |
| Author: | Marx, Andreas; Summerer, Daniel |
| Year of publication: | 2002 |
| Published in: | ChemBioChem ; 3 (2002), 5. - pp. 405-407. - ISSN 1439-4227. - eISSN 1439-7633 |
| DOI (citable link): | https://dx.doi.org/10.1002/1439-7633(20020503)3:5<405::AID-CBIC405>3.0.CO;2-4 |
| Summary: |
New DNA polymerase structures that differ significantly from known high-fidelity DNA polymerases provide new insights into how polymerases bypass damaged DNA like 1. Crystal structures of several Y-family DNA polymerases have recently been solved (see right-hand picture) and suggest that more open active sites may be the reason for the error propensity of low-fidelity polymerases.
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| Subject (DDC): | 540 Chemistry |
| Keywords: | DNA damage, DNA polymerases, DNA replication, thymidine dimers, UV light |
| Link to License: | Terms of use |
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MARX, Andreas, Daniel SUMMERER, 2002. Molecular Insights into Error-Prone DNA Replication and Error-Free Lesion Bypass. In: ChemBioChem. 3(5), pp. 405-407. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/1439-7633(20020503)3:5<405::AID-CBIC405>3.0.CO;2-4
@article{Marx2002Molec-9607, title={Molecular Insights into Error-Prone DNA Replication and Error-Free Lesion Bypass}, year={2002}, doi={10.1002/1439-7633(20020503)3:5<405::AID-CBIC405>3.0.CO;2-4}, number={5}, volume={3}, issn={1439-4227}, journal={ChemBioChem}, pages={405--407}, author={Marx, Andreas and Summerer, Daniel} }
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