KOPS - Das Institutionelle Repositorium der Universität Konstanz

Cyanopeptolin 954, a Chlorine-Containing Chymotrypsin Inhibitor of Microcystis aeruginosa NIVA Cya 43

Cyanopeptolin 954, a Chlorine-Containing Chymotrypsin Inhibitor of Microcystis aeruginosa NIVA Cya 43

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:7072b3ea4b451bf7e30c8aab5c19857f

ELERT, Eric von, Lukas OBERER, Petra MERKEL, Thomas HUHN, Judith F. BLOM, 2005. Cyanopeptolin 954, a Chlorine-Containing Chymotrypsin Inhibitor of Microcystis aeruginosa NIVA Cya 43. In: Journal of Natural Products. 68(9), pp. 1324-1327. ISSN 0163-3864. eISSN 1520-6025. Available under: doi: 10.1021/np050079r

@article{Elert2005Cyano-9588, title={Cyanopeptolin 954, a Chlorine-Containing Chymotrypsin Inhibitor of Microcystis aeruginosa NIVA Cya 43}, year={2005}, doi={10.1021/np050079r}, number={9}, volume={68}, issn={0163-3864}, journal={Journal of Natural Products}, pages={1324--1327}, author={Elert, Eric von and Oberer, Lukas and Merkel, Petra and Huhn, Thomas and Blom, Judith F.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/9588"> <dcterms:title>Cyanopeptolin 954, a Chlorine-Containing Chymotrypsin Inhibitor of Microcystis aeruginosa NIVA Cya 43</dcterms:title> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dc:rights>deposit-license</dc:rights> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Oberer, Lukas</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dc:creator>Elert, Eric von</dc:creator> <dc:contributor>Huhn, Thomas</dc:contributor> <dc:format>application/pdf</dc:format> <dcterms:bibliographicCitation>First publ. in: Journal of Natural Products ; 68 (2005), 9. - S. 1324-1327</dcterms:bibliographicCitation> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Merkel, Petra</dc:creator> <dc:creator>Oberer, Lukas</dc:creator> <dc:contributor>Merkel, Petra</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:12:57Z</dc:date> <dc:contributor>Elert, Eric von</dc:contributor> <dc:creator>Huhn, Thomas</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/9588/1/JNatProd2005.pdf"/> <dc:contributor>Blom, Judith F.</dc:contributor> <dc:creator>Blom, Judith F.</dc:creator> <dcterms:abstract xml:lang="eng">A new depsipeptide, cyanopeptolin 954 (1), was isolated from the freshwater cyanobacterium Microcystis aeruginosa NIVA Cya 43. The structure of the compound was elucidated by chemical and spectroscopic analyses, including 2D NMR and GC-MS of the hydrolysate. The major structural differences compared to previously characterized heptadepsipeptides of Microcystis are the replacement of the basic amino acid in position 4 by l-leucine, the presence of l-phenylalanine in position 6, and the uncommon residue 3 -chloro-N-Me-l-tyrosine in position 7. Cyanopeptolin 954 inhibited chymotrypsin with an IC50 value of 45 nM. Nostopeptin BN920, formerly isolated from the cyanobacterium Nostoc,1 was isolated from the same strain of Microcystis, and a cis amide bond between Phe (6) and N-Me-Tyr (7) was shown. Nostopeptin BN920 inhibited chymotrypsin with an IC50 value of 31 nM.</dcterms:abstract> <dcterms:issued>2005</dcterms:issued> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/9588"/> <dc:language>eng</dc:language> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/9588/1/JNatProd2005.pdf"/> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

JNatProd2005.pdf 123

Das Dokument erscheint in:

deposit-license Solange nicht anders angezeigt, wird die Lizenz wie folgt beschrieben: deposit-license

KOPS Suche


Stöbern

Mein Benutzerkonto