Total synthesis of (-)-8-O-methyltetrangomycin (MM 47755)

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KESENHEIMER, Christian, Ulrich GROTH, 2006. Total synthesis of (-)-8-O-methyltetrangomycin (MM 47755). In: Organic Letters. 8(12), pp. 2507-2510. ISSN 1523-7060. eISSN 1523-7052

@article{Kesenheimer2006Total-9551, title={Total synthesis of (-)-8-O-methyltetrangomycin (MM 47755)}, year={2006}, doi={10.1021/ol060667b}, number={12}, volume={8}, issn={1523-7060}, journal={Organic Letters}, pages={2507--2510}, author={Kesenheimer, Christian and Groth, Ulrich} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/9551"> <dc:contributor>Kesenheimer, Christian</dc:contributor> <dcterms:title>Total synthesis of (-)-8-O-methyltetrangomycin (MM 47755)</dcterms:title> <dc:rights>deposit-license</dc:rights> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:creator>Kesenheimer, Christian</dc:creator> <dcterms:issued>2006</dcterms:issued> <dcterms:abstract xml:lang="eng">A stereoselective total synthesis of the natural antibiotic (-)-8-O-methyltetrangomycin 1 is reported. The essential steps for this convergent synthesis are the transformation of a geraniol epoxide into a chiral octadiyne derivative, which was converted into a triyne. The cobalt-mediated [2+2+2] cycloaddition of the triyne led to a benz[a]anthracene system, which was oxidized with Ag(Py)2MnO4 to a benz[a]anthraquinone. Deprotection with aqueous HF in acetonitrile and photooxidation afforded the desired product (-)-1.</dcterms:abstract> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:12:41Z</dc:date> <dcterms:bibliographicCitation>First publ. in: Organic Letters ; 8 (2006), 12. - S. 2507-2510</dcterms:bibliographicCitation> <dc:creator>Groth, Ulrich</dc:creator> <dc:contributor>Groth, Ulrich</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/9551"/> <dc:format>application/pdf</dc:format> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>

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