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Non-Invasive Detection of Functional Brain Activity with Near-Infrared Diffusing-Wave Spectroscopy

Non-Invasive Detection of Functional Brain Activity with Near-Infrared Diffusing-Wave Spectroscopy

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LI, Jun, Gregor DIETSCHE, Diana IFTIME, Sergey E. SKIPETROV, Brigitte ROCKSTROH, Georg MARET, Thomas ELBERT, Thomas GISLER, 2004. Non-Invasive Detection of Functional Brain Activity with Near-Infrared Diffusing-Wave Spectroscopy. In: Journal of biomedical optics. 10(4), 44002

@article{Li2004Non-I-8960, title={Non-Invasive Detection of Functional Brain Activity with Near-Infrared Diffusing-Wave Spectroscopy}, year={2004}, doi={10.1117/1.2007987}, number={4}, volume={10}, journal={Journal of biomedical optics}, author={Li, Jun and Dietsche, Gregor and Iftime, Diana and Skipetrov, Sergey E. and Rockstroh, Brigitte and Maret, Georg and Elbert, Thomas and Gisler, Thomas}, note={Article Number: 44002} }

2011-03-24T17:52:25Z 2011-03-24T17:52:25Z Dietsche, Gregor deposit-license Maret, Georg Gisler, Thomas Elbert, Thomas Skipetrov, Sergey E. application/pdf Iftime, Diana Dietsche, Gregor Iftime, Diana Li, Jun Near-infrared dynamic multiple scattering of light (diffusing-wave spectroscopy, DWS) is introduced as a new method for non-invasive measurement of functional brain activity in humans. DWS was used to detect activation of the somato-motor cortex in 11 right-handed volunteers who performed a finger opposition task separately with their right and with their left hand. Temporal autocorrelation functions g(1)(¿ ) of the scattered light field were measured during 100 s periods of motor task alternating with 100 s resting baseline periods. Analyzing the experimental data with an analytical theory for g(1)(¿ ) from a 3-layer geometry with optical and dynamical heterogeneity representing scalp, skull and cortex allowed to isolate the di®usion coe±cient in cortical regions. During the motor task the cortical di®usion coe±cient was found to be significantly increased, indicating enhanced activation-related dynamics in active cortical tissue. As expected from known brain hemispheric asymmetry for right-handed subjects the contralateral response was more pronounced than the ipsilateral response. These results suggest that near-infrared DWS can be used<br />to non-invasively investigate subcellular dynamics in the cerebral cortex. Non-Invasive Detection of Functional Brain Activity with Near-Infrared Diffusing-Wave Spectroscopy First publ. in: Journal of biomedical optics 10 (2005), 4, 044002 Li, Jun Elbert, Thomas Rockstroh, Brigitte eng Skipetrov, Sergey E. 2004 Gisler, Thomas Maret, Georg Rockstroh, Brigitte

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