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The spatiotemporal distribution of N-CAM in the retinotectal pathway of adult goldfish detected by the monoclonal antibody D3

The spatiotemporal distribution of N-CAM in the retinotectal pathway of adult goldfish detected by the monoclonal antibody D3

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BASTMEYER, Martin, Burkhard SCHLOSSHAUER, Claudia STÜRMER, 1990. The spatiotemporal distribution of N-CAM in the retinotectal pathway of adult goldfish detected by the monoclonal antibody D3. In: Development. 108(2), pp. 299-311

@article{Bastmeyer1990spati-8830, title={The spatiotemporal distribution of N-CAM in the retinotectal pathway of adult goldfish detected by the monoclonal antibody D3}, year={1990}, number={2}, volume={108}, journal={Development}, pages={299--311}, author={Bastmeyer, Martin and Schlosshauer, Burkhard and Stürmer, Claudia} }

Stürmer, Claudia 2011-03-24T17:47:10Z 2011-03-24T17:47:10Z The spatiotemporal distribution of neural cell adhesion molecule (N-CAM) in the retinotectal system of adult goldfish was assessed by immunofluorescence using the monoclonal antibody (Mab) D3 against chick N-CAM. In immunoblots with extracts of cell surface membranes of fish brains, Mab D3 recognized a prominent band at 170K and a weak band at 130K (K=103Afr). N-CAM immunofluorescence on cells was restricted to the marginal growth zones of the retina and the tectum and, in normal fish, to the youngest axons from the new ganglion cells of the peripheral retinal margin. In fish with previously transected optic nerves (ONS), Mab D3 staining was found transiently on all axons from the site of the cut into the retinorecipient layers of the tectum, but disappeared from these axons 450 days after ONS. Growing retinal axons in vitro exhibited N-CAM immunofluorescence throughout their entire extent, including their growth cones. Glial cells cultured from regenerating optic nerves were, however, unlabeled.<br />These data are consistent with the idea that N-CAM is involved in adhesive interactions of growing axons. The temporally regulated expression of N-CAM on the new retinal axons may contribute to the creation of the agerelated organization of the axons in the retinotectal pathway of fish. Stürmer, Claudia Schlosshauer, Burkhard The spatiotemporal distribution of N-CAM in the retinotectal pathway of adult goldfish detected by the monoclonal antibody D3 Schlosshauer, Burkhard application/pdf First publ. in: Development ; 108 (1990). - S. 299-311 Bastmeyer, Martin 1990 eng deposit-license Bastmeyer, Martin

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