@article{Sturmer2004-11cappi-8817,
  year={2004},
  doi={10.1096/fj.04-2150fje},
  title={PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction : [Langfassung]},
  number={14},
  volume={18},
  issn={0892-6638},
  journal={The FASEB Journal},
  pages={1731--1733},
  author={Stürmer, Claudia and Langhorst, Matthias F. and Wiechers, Marianne F. and Legler, Daniel and Hannbeck von Hanwehr, Sylvia and Guse, Andreas H. and Plattner, Helmut},
  note={"published ahead of print September 2, 2004"  - deswegen ohne Seitenzahlen}
}

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    <dc:contributor>Guse, Andreas H.</dc:contributor>
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    <dc:contributor>Wiechers, Marianne F.</dc:contributor>
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    <dc:creator>Plattner, Helmut</dc:creator>
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    <dc:creator>Hannbeck von Hanwehr, Sylvia</dc:creator>
    <dc:contributor>Stürmer, Claudia</dc:contributor>
    <dcterms:title>PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction : [Langfassung]</dcterms:title>
    <dc:creator>Guse, Andreas H.</dc:creator>
    <dc:contributor>Langhorst, Matthias F.</dc:contributor>
    <dc:creator>Langhorst, Matthias F.</dc:creator>
    <dc:creator>Legler, Daniel</dc:creator>
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    <dcterms:abstract xml:lang="eng">The cellular prion protein (PrPc) resides in lipid rafts, yet the type of raft and the physiological function of PrPc are unclear. We show here that cross-linking of PrPc with specific antibodies leads to 1) PrPc capping in Jurkat and human peripheral blood T cells; 2) to cocapping with the intracellular lipid raft proteins reggie-1 and reggie-2; 3) to signal transduction as seen by MAP kinase phosphorylation and an elevation of the intracellular Ca2+ concentration; 4) to the recruitment of Thy-1, TCR/CD3, fyn, lck and LAT into the cap along with local tyrosine phosphorylation and F-actin polymerization, and later, internalization of PrPc together with the reggies into limp-2 positive lysosomes. Thus, PrPc association with reggie rafts triggers distinct transmembrane signal transduction events in T cells that promote the focal concentration of PrPc itself by guiding activated PrPc into preformed reggie caps and then to the recruitment of important interacting signaling molecules.</dcterms:abstract>
    <dc:creator>Wiechers, Marianne F.</dc:creator>
    <dcterms:bibliographicCitation>First publ. in: The FASEB Journal ; 101 (2004)</dcterms:bibliographicCitation>
    <dcterms:issued>2004-11</dcterms:issued>
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