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PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction : [Langfassung]

PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction : [Langfassung]

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STÜRMER, Claudia, Matthias F. LANGHORST, Marianne F. WIECHERS, Daniel F. LEGLER, Sylvia HANNBECK VON HANWEHR, Andreas H. GUSE, Helmut PLATTNER, 2004. PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction : [Langfassung]. In: The FASEB Journal. 18(14), pp. 1731-1733. ISSN 0892-6638. eISSN 1530-6860. Available under: doi: 10.1096/fj.04-2150fje

@article{Sturmer2004-11cappi-8817, title={PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction : [Langfassung]}, year={2004}, doi={10.1096/fj.04-2150fje}, number={14}, volume={18}, issn={0892-6638}, journal={The FASEB Journal}, pages={1731--1733}, author={Stürmer, Claudia and Langhorst, Matthias F. and Wiechers, Marianne F. and Legler, Daniel F. and Hannbeck von Hanwehr, Sylvia and Guse, Andreas H. and Plattner, Helmut}, note={"published ahead of print September 2, 2004" - deswegen ohne Seitenzahlen} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8817"> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Langhorst, Matthias F.</dc:contributor> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:creator>Hannbeck von Hanwehr, Sylvia</dc:creator> <dc:creator>Stürmer, Claudia</dc:creator> <dc:contributor>Plattner, Helmut</dc:contributor> <dc:creator>Plattner, Helmut</dc:creator> <dc:creator>Wiechers, Marianne F.</dc:creator> <dc:creator>Langhorst, Matthias F.</dc:creator> <dc:contributor>Guse, Andreas H.</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:46:40Z</dcterms:available> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8817"/> <dc:rights>deposit-license</dc:rights> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:46:40Z</dc:date> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Guse, Andreas H.</dc:creator> <dc:contributor>Wiechers, Marianne F.</dc:contributor> <dcterms:abstract xml:lang="eng">The cellular prion protein (PrPc) resides in lipid rafts, yet the type of raft and the physiological function of PrPc are unclear. We show here that cross-linking of PrPc with specific antibodies leads to 1) PrPc capping in Jurkat and human peripheral blood T cells; 2) to cocapping with the intracellular lipid raft proteins reggie-1 and reggie-2; 3) to signal transduction as seen by MAP kinase phosphorylation and an elevation of the intracellular Ca2+ concentration; 4) to the recruitment of Thy-1, TCR/CD3, fyn, lck and LAT into the cap along with local tyrosine phosphorylation and F-actin polymerization, and later, internalization of PrPc together with the reggies into limp-2 positive lysosomes. Thus, PrPc association with reggie rafts triggers distinct transmembrane signal transduction events in T cells that promote the focal concentration of PrPc itself by guiding activated PrPc into preformed reggie caps and then to the recruitment of important interacting signaling molecules.</dcterms:abstract> <dc:format>application/pdf</dc:format> <dc:language>eng</dc:language> <dc:contributor>Stürmer, Claudia</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8817/1/102_HrPc_capping_in_T_cells.pdf"/> <dc:creator>Legler, Daniel F.</dc:creator> <dc:contributor>Hannbeck von Hanwehr, Sylvia</dc:contributor> <dcterms:title>PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction : [Langfassung]</dcterms:title> <dcterms:bibliographicCitation>First publ. in: The FASEB Journal ; 101 (2004)</dcterms:bibliographicCitation> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8817/1/102_HrPc_capping_in_T_cells.pdf"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:issued>2004-11</dcterms:issued> <dc:contributor>Legler, Daniel F.</dc:contributor> </rdf:Description> </rdf:RDF>

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