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Genome desertification in eutherians : can gene deserts explain the uneven distribution of genes in placental mammalian genomes?

Genome desertification in eutherians : can gene deserts explain the uneven distribution of genes in placental mammalian genomes?

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SALZBURGER, Walter, Dirk STEINKE, Ingo BRAASCH, Axel MEYER, 2009. Genome desertification in eutherians : can gene deserts explain the uneven distribution of genes in placental mammalian genomes?. In: Journal of Molecular Evolution. 69(3), pp. 207-216. ISSN 0022-2844. eISSN 1432-1432

@article{Salzburger2009Genom-8809, title={Genome desertification in eutherians : can gene deserts explain the uneven distribution of genes in placental mammalian genomes?}, year={2009}, doi={10.1007/s00239-009-9251-4}, number={3}, volume={69}, issn={0022-2844}, journal={Journal of Molecular Evolution}, pages={207--216}, author={Salzburger, Walter and Steinke, Dirk and Braasch, Ingo and Meyer, Axel} }

Steinke, Dirk Braasch, Ingo Braasch, Ingo The evolution of genome size as well as structure and organization of genomes belongs among the key questions of genome biology. Here we show, based on a comparative analysis of 30 genomes, that there is generally a tight correlation between the number of genes per chromosome and the length of the respective chromosome in eukaryotic genomes. The surprising exceptions to this pattern are placental mammalian genomes. We identify the number and, more importantly, the uneven distribution of gene deserts among chromosomes, i.e., long (>500 kb) stretches of DNA that do not encode for genes, as the main contributing factor for the observed anomaly of eutherian genomes. Gene-rich placental mammalian chromosomes have smaller proportions of gene deserts and vice versa. We show that the uneven distribution of gene deserts is a derived character state of eutherians. The functional and evolutionary significance of this particular feature of eutherian genomes remains to be explained. Steinke, Dirk eng Meyer, Axel deposit-license Salzburger, Walter 2011-03-24T17:46:37Z Genome desertification in eutherians : can gene deserts explain the uneven distribution of genes in placental mammalian genomes? Salzburger, Walter 2009 Meyer, Axel First publ. in: Journal of Molecular Evolution ; 69 (2009), 3. - S. 207-216 application/pdf

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