Aufgrund von Vorbereitungen auf eine neue Version von KOPS, können kommenden Montag und Dienstag keine Publikationen eingereicht werden. (Due to preparations for a new version of KOPS, no publications can be submitted next Monday and Tuesday.)
Type of Publication: | Journal article |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-79685 |
Author: | Stadelmaier, Andreas; Figueroa-Perez, Ignacio; Deininger, Susanne; Aulock, Sonja von; Hartung, Thomas; Schmidt, Richard R. |
Year of publication: | 2006 |
Published in: | Bioorganic & Medicinal Chemistry ; 14 (2006), 18. - pp. 6239-6254. - ISSN 0968-0896 |
Pubmed ID: | 16782351 |
DOI (citable link): | https://dx.doi.org/10.1016/j.bmc.2006.05.055 |
Summary: |
Based on 1,2 O isopropylidene O glycerol five chiral building blocks containing differently modified glycerol residues were required for the synthesis of the target molecule 2. One of these building blocks is diacylglyceryl β gentiobioside carrying a phosphite residue at 6b O position. Ligation of these five building blocks led to the desired glycerol phosphate backbone to which D alanyl residues were attached, thus generating after O deprotection the target molecule 2, a bisamphiphilic structural variant of Staphylococcus aureus LTA. This compound displayed higher potency in terms of cytokine release by human blood leukocytes than the monoamphiphilic variant LTA.
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Subject (DDC): | 570 Biosciences, Biology |
Link to License: | In Copyright |
Bibliography of Konstanz: | Yes |
STADELMAIER, Andreas, Ignacio FIGUEROA-PEREZ, Susanne DEININGER, Sonja von AULOCK, Thomas HARTUNG, Richard R. SCHMIDT, 2006. A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues. In: Bioorganic & Medicinal Chemistry. 14(18), pp. 6239-6254. ISSN 0968-0896. Available under: doi: 10.1016/j.bmc.2006.05.055
@article{Stadelmaier2006Staph-8786, title={A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues}, year={2006}, doi={10.1016/j.bmc.2006.05.055}, number={18}, volume={14}, issn={0968-0896}, journal={Bioorganic & Medicinal Chemistry}, pages={6239--6254}, author={Stadelmaier, Andreas and Figueroa-Perez, Ignacio and Deininger, Susanne and Aulock, Sonja von and Hartung, Thomas and Schmidt, Richard R.} }
2006Stadelmaier_galley_proofs_BMC_bearb.pdf | 372 |