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A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues

A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues

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Prüfsumme: MD5:946c9ddc7c6067ff2819cc1bda8c5a21

STADELMAIER, Andreas, Ignacio FIGUEROA-PEREZ, Susanne DEININGER, Sonja von AULOCK, Thomas HARTUNG, Richard R. SCHMIDT, 2006. A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues. In: Bioorganic & Medicinal Chemistry. 14(18), pp. 6239-6254. ISSN 0968-0896. Available under: doi: 10.1016/j.bmc.2006.05.055

@article{Stadelmaier2006Staph-8786, title={A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues}, year={2006}, doi={10.1016/j.bmc.2006.05.055}, number={18}, volume={14}, issn={0968-0896}, journal={Bioorganic & Medicinal Chemistry}, pages={6239--6254}, author={Stadelmaier, Andreas and Figueroa-Perez, Ignacio and Deininger, Susanne and Aulock, Sonja von and Hartung, Thomas and Schmidt, Richard R.} }

Figueroa-Perez, Ignacio 2011-03-24T17:46:27Z Schmidt, Richard R. eng A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues Schmidt, Richard R. 2011-03-24T17:46:27Z 2006 Stadelmaier, Andreas Figueroa-Perez, Ignacio Hartung, Thomas Deininger, Susanne Stadelmaier, Andreas deposit-license Hartung, Thomas application/pdf Aulock, Sonja von Deininger, Susanne Aulock, Sonja von First publ. in: Bioorganic & Medicinal Chemistry 14 (2006), 18, pp. 6239-6254 Based on 1,2 O isopropylidene O glycerol five chiral building blocks containing differently modified glycerol residues were required for the synthesis of the target molecule 2. One of these building blocks is diacylglyceryl β gentiobioside carrying a phosphite residue at 6b O position. Ligation of these five building blocks led to the desired glycerol phosphate backbone to which D alanyl residues were attached, thus generating after O deprotection the target molecule 2, a bisamphiphilic structural variant of Staphylococcus aureus LTA. This compound displayed higher potency in terms of cytokine release by human blood leukocytes than the monoamphiphilic variant LTA.

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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