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Toxin production in cyanobacterial mats from ponds on the McMurdo Ice Shelf, Antarctica

Toxin production in cyanobacterial mats from ponds on the McMurdo Ice Shelf, Antarctica


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HITZFELD, Bettina C., Christina S. LAMPERT, Nicola SPÄTH, Doug MOUNTFORT, Henry KASPAR, Daniel R. DIETRICH, 2000. Toxin production in cyanobacterial mats from ponds on the McMurdo Ice Shelf, Antarctica. In: Toxicon. 38(12), pp. 1731-1748. ISSN 0041-0101

@article{Hitzfeld2000Toxin-8778, title={Toxin production in cyanobacterial mats from ponds on the McMurdo Ice Shelf, Antarctica}, year={2000}, doi={10.1016/S0041-0101(00)00103-3}, number={12}, volume={38}, issn={0041-0101}, journal={Toxicon}, pages={1731--1748}, author={Hitzfeld, Bettina C. and Lampert, Christina S. and Späth, Nicola and Mountfort, Doug and Kaspar, Henry and Dietrich, Daniel R.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8778"> <dcterms:issued>2000</dcterms:issued> <dc:contributor>Hitzfeld, Bettina C.</dc:contributor> <dc:contributor>Mountfort, Doug</dc:contributor> <dc:format>application/pdf</dc:format> <dc:rights>deposit-license</dc:rights> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:46:23Z</dc:date> <dc:creator>Späth, Nicola</dc:creator> <dc:creator>Dietrich, Daniel R.</dc:creator> <dc:creator>Kaspar, Henry</dc:creator> <dcterms:abstract xml:lang="eng">Cyanobacteria are known to produce hepatotoxic substances, the functional and ecological role of these toxins, however, remains largely unclear. Toxic properties of cyanobacteria collected in Antarctica were investigated to determine whether toxin-producing species can also be found under these environmental conditions. Samples were collected from meltwater ponds on the McMurdo Ice Shelf, Antarctica in the summers of 1997 to 1999. These ponds are colonized by benthic algae and cyanobacterial mats. Oscillatoriales, Nodularia sp., and Nostoc sp. constituted the major taxa in freshwater ponds, while Nostoc sp. was missing from brackish and saline ponds. Samples were taken from either floating, submerged or benthic mats, and extracted for in vitro toxicity testing. The presence of toxins was determined by the phosphatase-inhibition assay and by high performance liquid chromatography. The cytotoxic properties of the extracts were investigated in hepatocytes determining 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide metabolism and trypan blue dye exclusion. The results show that all cyanobacterial extracts display phosphatase-inhibiting activity, of which approximately half had significantly greater than 50% inhibiting activity. The presence of nodularin and microcystin-LR was established by high performance liquid chromatography. Cytotoxic properties, independent of the phosphatase inhibiting activity, were also detected. Toxic strains of cyanobacteria can therefore also be found in Antarctica and this finding may lead to further insight into potential ecological roles of cyanobacterial phosphatase inhibiting toxins.</dcterms:abstract> <dcterms:bibliographicCitation>First publ. in: Toxicon 38 (2000), 12, pp. 1731-1748</dcterms:bibliographicCitation> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:46:23Z</dcterms:available> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8778"/> <dc:contributor>Lampert, Christina S.</dc:contributor> <dc:contributor>Dietrich, Daniel R.</dc:contributor> <dc:creator>Mountfort, Doug</dc:creator> <dc:creator>Hitzfeld, Bettina C.</dc:creator> <dc:contributor>Kaspar, Henry</dc:contributor> <dcterms:title>Toxin production in cyanobacterial mats from ponds on the McMurdo Ice Shelf, Antarctica</dcterms:title> <dc:language>eng</dc:language> <dc:creator>Lampert, Christina S.</dc:creator> <dc:contributor>Späth, Nicola</dc:contributor> </rdf:Description> </rdf:RDF>

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