Effect of zinc on cellular poly(ADP-ribosyl)ation capacity

Publikationstyp: Zeitschriftenartikel
URI (zitierfähiger Link): http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-77519
Autor/innen: Kunzmann, Andrea; Dedoussis, George; Jajte, Jolanta; Malavolta, Marco; Mocchegiani, Eugenio; Bürkle, Alexander
Erscheinungsjahr: 2007
Erschienen in: Experimental Gerontology ; 43 (2007), 5. - S. 409-414. - ISSN 0531-5565
Pubmed ID: 18022337
DOI (zitierfähiger Link): https://dx.doi.org/10.1016/j.exger.2007.10.003
Zusammenfassung:
Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability. A decrease in cellular poly(ADP-ribosyl)ation has been implicated in the aging process. As PARP-1 is a zinc finger protein its decreased function might be related to age-related zinc deficiency. To test this hypothesis we assessed cellular poly(ADP-ribosyl)ation capacity in 29 donors from Greece, Italy and Poland as function of age and nutritional zinc status. Our results reveal a positive correlation between cellular poly(ADP-ribosyl)ation capacity and zinc status in human peripheral blood mononuclear cells (PBMC) (p < 0.05). We could also confirm a decrease of PARP-1 activity with donor age, highlighting the role of poly(ADP-ribosyl)ation in the aging process. The results demonstrate that zinc supplementation in elderly people can increase the cellular poly(ADP-ribosyl)ation capacity of their PBMC. We speculate that this may help maintain integrity and stability of the genome more efficiently and thus contribute to an extension of healthspan.
Fachgebiet (DDC): 570 Biowissenschaften, Biologie
Schlagwörter: PARP-1, Poly(ADP-ribosyl)ation capacity, Zinc supplementation, Aging
Link zur Lizenz: Deposit-Lizenz
Universitätsbibliographie: Ja

Zitieren

Dateien zu dieser Ressource

[PDF]
Name: ExpGerontology_2007_Kunzmann_et_al.pdf
Größe: 171.6Kb
Format: PDF
Öffnen
Prüfsumme: MD5:59905b06f1efc2718726ca2693bf9c85

KUNZMANN, Andrea, George DEDOUSSIS, Jolanta JAJTE, Marco MALAVOLTA, Eugenio MOCCHEGIANI, Alexander BÜRKLE, 2007. Effect of zinc on cellular poly(ADP-ribosyl)ation capacity. In: Experimental Gerontology. 43(5), pp. 409-414. ISSN 0531-5565

@article{Kunzmann2007Effec-8768, title={Effect of zinc on cellular poly(ADP-ribosyl)ation capacity}, year={2007}, doi={10.1016/j.exger.2007.10.003}, number={5}, volume={43}, issn={0531-5565}, journal={Experimental Gerontology}, pages={409--414}, author={Kunzmann, Andrea and Dedoussis, George and Jajte, Jolanta and Malavolta, Marco and Mocchegiani, Eugenio and Bürkle, Alexander} }

Bürkle, Alexander Malavolta, Marco application/pdf 2007 Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability. A decrease in cellular poly(ADP-ribosyl)ation has been implicated in the aging process. As PARP-1 is a zinc finger protein its decreased function might be related to age-related zinc deficiency. To test this hypothesis we assessed cellular poly(ADP-ribosyl)ation capacity in 29 donors from Greece, Italy and Poland as function of age and nutritional zinc status. Our results reveal a positive correlation between cellular poly(ADP-ribosyl)ation capacity and zinc status in human peripheral blood mononuclear cells (PBMC) (p < 0.05). We could also confirm a decrease of PARP-1 activity with donor age, highlighting the role of poly(ADP-ribosyl)ation in the aging process. The results demonstrate that zinc supplementation in elderly people can increase the cellular poly(ADP-ribosyl)ation capacity of their PBMC. We speculate that this may help maintain integrity and stability of the genome more efficiently and thus contribute to an extension of healthspan. Jajte, Jolanta Dedoussis, George First publ. in: Experimental Gerontology 43 (2008), 5, pp. 409-414 Kunzmann, Andrea Dedoussis, George 2011-03-24T17:46:18Z Malavolta, Marco Mocchegiani, Eugenio eng deposit-license Mocchegiani, Eugenio Bürkle, Alexander Kunzmann, Andrea Jajte, Jolanta 2011-03-24T17:46:18Z Effect of zinc on cellular poly(ADP-ribosyl)ation capacity

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

ExpGerontology_2007_Kunzmann_et_al.pdf 158

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto