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Type of Publication: | Journal article |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-77519 |
Author: | Kunzmann, Andrea; Dedoussis, George; Jajte, Jolanta; Malavolta, Marco; Mocchegiani, Eugenio; Bürkle, Alexander |
Year of publication: | 2007 |
Published in: | Experimental Gerontology ; 43 (2007), 5. - pp. 409-414. - ISSN 0531-5565 |
Pubmed ID: | 18022337 |
DOI (citable link): | https://dx.doi.org/10.1016/j.exger.2007.10.003 |
Summary: |
Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability. A decrease in cellular poly(ADP-ribosyl)ation has been implicated in the aging process. As PARP-1 is a zinc finger protein its decreased function might be related to age-related zinc deficiency. To test this hypothesis we assessed cellular poly(ADP-ribosyl)ation capacity in 29 donors from Greece, Italy and Poland as function of age and nutritional zinc status. Our results reveal a positive correlation between cellular poly(ADP-ribosyl)ation capacity and zinc status in human peripheral blood mononuclear cells (PBMC) (p < 0.05). We could also confirm a decrease of PARP-1 activity with donor age, highlighting the role of poly(ADP-ribosyl)ation in the aging process. The results demonstrate that zinc supplementation in elderly people can increase the cellular poly(ADP-ribosyl)ation capacity of their PBMC. We speculate that this may help maintain integrity and stability of the genome more efficiently and thus contribute to an extension of healthspan.
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Subject (DDC): | 570 Biosciences, Biology |
Keywords: | PARP-1, Poly(ADP-ribosyl)ation capacity, Zinc supplementation, Aging |
Link to License: | In Copyright |
Bibliography of Konstanz: | Yes |
KUNZMANN, Andrea, George DEDOUSSIS, Jolanta JAJTE, Marco MALAVOLTA, Eugenio MOCCHEGIANI, Alexander BÜRKLE, 2007. Effect of zinc on cellular poly(ADP-ribosyl)ation capacity. In: Experimental Gerontology. 43(5), pp. 409-414. ISSN 0531-5565. Available under: doi: 10.1016/j.exger.2007.10.003
@article{Kunzmann2007Effec-8768, title={Effect of zinc on cellular poly(ADP-ribosyl)ation capacity}, year={2007}, doi={10.1016/j.exger.2007.10.003}, number={5}, volume={43}, issn={0531-5565}, journal={Experimental Gerontology}, pages={409--414}, author={Kunzmann, Andrea and Dedoussis, George and Jajte, Jolanta and Malavolta, Marco and Mocchegiani, Eugenio and Bürkle, Alexander} }
ExpGerontology_2007_Kunzmann_et_al.pdf | 827 |