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Effect of zinc on cellular poly(ADP-ribosyl)ation capacity

Type of Publication: Journal article
URI (citable link): http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-77519
Author: Kunzmann, Andrea; Dedoussis, George; Jajte, Jolanta; Malavolta, Marco; Mocchegiani, Eugenio; Bürkle, Alexander
Year of publication: 2007
Published in: Experimental Gerontology ; 43 (2007), 5. - pp. 409-414. - ISSN 0531-5565
Pubmed ID: 18022337
DOI (citable link): https://dx.doi.org/10.1016/j.exger.2007.10.003
Summary:
Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability. A decrease in cellular poly(ADP-ribosyl)ation has been implicated in the aging process. As PARP-1 is a zinc finger protein its decreased function might be related to age-related zinc deficiency. To test this hypothesis we assessed cellular poly(ADP-ribosyl)ation capacity in 29 donors from Greece, Italy and Poland as function of age and nutritional zinc status. Our results reveal a positive correlation between cellular poly(ADP-ribosyl)ation capacity and zinc status in human peripheral blood mononuclear cells (PBMC) (p < 0.05). We could also confirm a decrease of PARP-1 activity with donor age, highlighting the role of poly(ADP-ribosyl)ation in the aging process. The results demonstrate that zinc supplementation in elderly people can increase the cellular poly(ADP-ribosyl)ation capacity of their PBMC. We speculate that this may help maintain integrity and stability of the genome more efficiently and thus contribute to an extension of healthspan.
Subject (DDC): 570 Biosciences, Biology
Keywords: PARP-1, Poly(ADP-ribosyl)ation capacity, Zinc supplementation, Aging
Link to License: In Copyright
Bibliography of Konstanz: Yes

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KUNZMANN, Andrea, George DEDOUSSIS, Jolanta JAJTE, Marco MALAVOLTA, Eugenio MOCCHEGIANI, Alexander BÜRKLE, 2007. Effect of zinc on cellular poly(ADP-ribosyl)ation capacity. In: Experimental Gerontology. 43(5), pp. 409-414. ISSN 0531-5565. Available under: doi: 10.1016/j.exger.2007.10.003

@article{Kunzmann2007Effec-8768, title={Effect of zinc on cellular poly(ADP-ribosyl)ation capacity}, year={2007}, doi={10.1016/j.exger.2007.10.003}, number={5}, volume={43}, issn={0531-5565}, journal={Experimental Gerontology}, pages={409--414}, author={Kunzmann, Andrea and Dedoussis, George and Jajte, Jolanta and Malavolta, Marco and Mocchegiani, Eugenio and Bürkle, Alexander} }

Bürkle, Alexander Malavolta, Marco application/pdf 2007 Dedoussis, George Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability. A decrease in cellular poly(ADP-ribosyl)ation has been implicated in the aging process. As PARP-1 is a zinc finger protein its decreased function might be related to age-related zinc deficiency. To test this hypothesis we assessed cellular poly(ADP-ribosyl)ation capacity in 29 donors from Greece, Italy and Poland as function of age and nutritional zinc status. Our results reveal a positive correlation between cellular poly(ADP-ribosyl)ation capacity and zinc status in human peripheral blood mononuclear cells (PBMC) (p < 0.05). We could also confirm a decrease of PARP-1 activity with donor age, highlighting the role of poly(ADP-ribosyl)ation in the aging process. The results demonstrate that zinc supplementation in elderly people can increase the cellular poly(ADP-ribosyl)ation capacity of their PBMC. We speculate that this may help maintain integrity and stability of the genome more efficiently and thus contribute to an extension of healthspan. Jajte, Jolanta First publ. in: Experimental Gerontology 43 (2008), 5, pp. 409-414 Kunzmann, Andrea Malavolta, Marco Dedoussis, George 2011-03-24T17:46:18Z Mocchegiani, Eugenio eng Mocchegiani, Eugenio Bürkle, Alexander Kunzmann, Andrea Jajte, Jolanta terms-of-use 2011-03-24T17:46:18Z Effect of zinc on cellular poly(ADP-ribosyl)ation capacity

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