Properties of flavins where the 8-Methyl group is replaced by mercapto-Residues


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MOORE, Edwin G., Sandro GHISLA, Vincent MASSEY, 1979. Properties of flavins where the 8-Methyl group is replaced by mercapto-Residues. In: Journal of Biological Chemistry. 254(17), pp. 8173-8178

@article{Moore1979Prope-8745, title={Properties of flavins where the 8-Methyl group is replaced by mercapto-Residues}, year={1979}, number={17}, volume={254}, journal={Journal of Biological Chemistry}, pages={8173--8178}, author={Moore, Edwin G. and Ghisla, Sandro and Massey, Vincent} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Ghisla, Sandro</dc:creator> <dc:date rdf:datatype="">2011-03-24T17:46:09Z</dc:date> <dcterms:title>Properties of flavins where the 8-Methyl group is replaced by mercapto-Residues</dcterms:title> <dcterms:abstract xml:lang="eng">Sulfur functions in position 8 of the flavin nucleus give rise to new modified flavin derivatives, which should prove useful as probes of the flavin binding domains of flavoproteins. Here, we report on some properties of 8-nor-8-alkylmercaptoflavins and 8-nor-8-mercaptoflavin which are readily formed by nucleophilic displacement by alkylmercaptides or sulfide, with 8-nor-8-chloroflavins as starting material. The new flavins are characterized by extensive shifts in spectral properties, with very high extinction coefficients. 8-nor-8-mercaptoriboflavin is easily and reversibly converted to its (-S-S-) dimer. Oxidation of the sulfur group by peracids forms first sulfoxides and then sulfones, in which the characteristic usual flavin spectrum is regained. A comparison of 8-SR-8-nor-flavins with 8-OR-8-nor-flavins (Ghisla, S., and Mayhew, S. G. (1976) Eur. J. Biochem 63, 373-390) indicates that in both classes of compounds, optical properties, ionization constants, and oxidation-reduction potentials follow similar patterns.</dcterms:abstract> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:hasPart rdf:resource=""/> <dc:language>eng</dc:language> <dcterms:bibliographicCitation>First publ. in: Journal of Biological Chemistry 254 (1979), 17, pp. 8173-8178</dcterms:bibliographicCitation> <dc:creator>Moore, Edwin G.</dc:creator> <dspace:isPartOfCollection rdf:resource=""/> <bibo:uri rdf:resource=""/> <dcterms:available rdf:datatype="">2011-03-24T17:46:09Z</dcterms:available> <dspace:hasBitstream rdf:resource=""/> <dcterms:rights rdf:resource=""/> <dc:contributor>Massey, Vincent</dc:contributor> <dc:contributor>Moore, Edwin G.</dc:contributor> <dcterms:isPartOf rdf:resource=""/> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Ghisla, Sandro</dc:contributor> <dc:creator>Massey, Vincent</dc:creator> <dcterms:issued>1979</dcterms:issued> <dc:format>application/pdf</dc:format> </rdf:Description> </rdf:RDF>

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