@article{Strauch2007TwoSt-8734,
  year={2007},
  doi={10.2390/biecoll-jib-2007-54},
  title={A Two-Step Clustering for 3-D Gene Expression Data Reveals theMain Features of the Arabidopsis Stress Response},
  number={1},
  volume={4},
  journal={Journal of Integrative Bioinformatics},
  author={Strauch, Martin and Supper, Jochen and Spieth, Christian and Wanke, Dierk and Kilian, Joachim and Harter, Klaus and Zell, Andreas},
  note={Article Number: 54}
}

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    <dc:creator>Wanke, Dierk</dc:creator>
    <dc:contributor>Spieth, Christian</dc:contributor>
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    <dc:contributor>Strauch, Martin</dc:contributor>
    <dc:contributor>Kilian, Joachim</dc:contributor>
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    <dcterms:abstract xml:lang="eng">We developed an integrative approach for discovering gene modules, i.e. genes that are tightly correlated under several experimental conditions and applied it to a threedimensional Arabidopsis thaliana microarray dataset. The dataset consists of approximately 23000 genes responding to 9 abiotic stress conditions at 6-9 different points in time. Our approach aims at finding relatively small and dense modules lending themselves to a specific biological interpretation. In order to detect gene modules within this dataset, we employ a two-step clustering process. In the first step, a k-means clustering on one condition is performed, which is subsequently used in the second step as a seed for the clustering of the remaining conditions. To validate the significance of the obtained modules, we performed a permutation analysis and determined a null hypothesis to compare the module scores against, providing a p-value for each module. Significant modules were mapped to the Gene Ontology (GO) in order to determine the participating biological processes.&lt;br /&gt;As a result, we isolated modules showing high significance with respect to the p-values obtained by permutation analysis and GO mapping. In these modules we identified a number of genes that are either part of a general stress response with similar characteristics under different conditions (coherent modules), or part of a more specific stress response to a single stress condition (single response modules). We also found genes clustering within several conditions, which are, however, not part of a coherent module. These genes have a distinct temporal response under each condition. We call the modules they are contained in individual response modules (IR).</dcterms:abstract>
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    <dc:contributor>Harter, Klaus</dc:contributor>
    <dc:creator>Kilian, Joachim</dc:creator>
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    <dcterms:bibliographicCitation>First publ. in: Journal of Integrative Bioinformatics 4 (2007), 1, 54</dcterms:bibliographicCitation>
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    <dc:contributor>Supper, Jochen</dc:contributor>
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    <dc:creator>Spieth, Christian</dc:creator>
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