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Matrix survival signaling : from fibronectin via focal adhesion kinase to c-Jun NH2-terminal kinase

Matrix survival signaling : from fibronectin via focal adhesion kinase to c-Jun NH2-terminal kinase

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ALMEIDA, Eduardo A.C., Du ko ILIĆ, Qin HAN, Christof R. HAUCK, Fang JIN, Hisaaki KAWAKATSU, David D. SCHLAEPFER, Caroline H. DAMSKY, 2000. Matrix survival signaling : from fibronectin via focal adhesion kinase to c-Jun NH2-terminal kinase. In: Journal of Cell Biology. 149(3), pp. 741-754. ISSN 0021-9525. Available under: doi: 10.1083/jcb.149.3.741

@article{Almeida2000Matri-8711, title={Matrix survival signaling : from fibronectin via focal adhesion kinase to c-Jun NH2-terminal kinase}, year={2000}, doi={10.1083/jcb.149.3.741}, number={3}, volume={149}, issn={0021-9525}, journal={Journal of Cell Biology}, pages={741--754}, author={Almeida, Eduardo A.C. and Ilić, Du ko and Han, Qin and Hauck, Christof R. and Jin, Fang and Kawakatsu, Hisaaki and Schlaepfer, David D. and Damsky, Caroline H.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8711"> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8711"/> <dc:rights>terms-of-use</dc:rights> <dcterms:title>Matrix survival signaling : from fibronectin via focal adhesion kinase to c-Jun NH2-terminal kinase</dcterms:title> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:45:52Z</dcterms:available> <dc:contributor>Han, Qin</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:45:52Z</dc:date> <dc:creator>Ilić, Du ko</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Damsky, Caroline H.</dc:creator> <dc:format>application/pdf</dc:format> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8711/1/Matrix_survival_signaling.pdf"/> <dc:creator>Hauck, Christof R.</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Ilić, Du ko</dc:contributor> <dc:contributor>Schlaepfer, David D.</dc:contributor> <dcterms:bibliographicCitation>First publ. in: Journal of Cell Biology 149 (2000), 3, pp. 741 754</dcterms:bibliographicCitation> <dc:contributor>Damsky, Caroline H.</dc:contributor> <dcterms:abstract xml:lang="eng">Most transformed cells have lost anchorage and serum dependence for growth and survival. Previously, we established that when serum is absent, fibronectin survival signals transduced by focal adhesion kinase (FAK), suppress p53-regulated apoptosis in primary fibroblasts and endothelial cells (Ili et al., 1998. J. Cell Biol. 143: 547 560). The present goals are to identify survival sequences in FAK and signaling molecules downstream of FAK required for anchorage-dependent survival of primary fibroblasts. We report that binding of the SH3 domain of p130Cas to proline-rich region 1 of FAK is required to support survival of fibroblasts on fibronectin when serum is withdrawn. The FAK p130Cas complex activates c-Jun NH2-terminal kinase (JNK) via a Ras/Rac1/Pak1/MAPK kinase 4 (MKK4) pathway. Activated (phospho-) JNK colocalizes with c´ FAK in focal adhesions of fibroblasts cultured on fibronectin, which supports their survival, but not in fibroblasts cultured on collagen, which does not. Cells often survive in the absence of extracellular matrix if serum factors are provided. In that case, we confirm work of others that survival signals are transduced by FAK, phosphatidylinositol 39-kinase (PI3-kinase), and Akt/protein kinase B (PKB). However, when serum is absent, PI3-kinase and Akt/PKB are not involved in the fibronectin-FAK-JNK survival pathway documented herein. Thus, survival signals from extracellular matrix and serum are transduced by FAK via two distinct pathways.</dcterms:abstract> <dc:creator>Han, Qin</dc:creator> <dc:language>eng</dc:language> <dc:creator>Kawakatsu, Hisaaki</dc:creator> <dc:contributor>Kawakatsu, Hisaaki</dc:contributor> <dcterms:issued>2000</dcterms:issued> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Hauck, Christof R.</dc:contributor> <dc:creator>Almeida, Eduardo A.C.</dc:creator> <dc:contributor>Jin, Fang</dc:contributor> <dc:contributor>Almeida, Eduardo A.C.</dc:contributor> <dc:creator>Schlaepfer, David D.</dc:creator> <dc:creator>Jin, Fang</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8711/1/Matrix_survival_signaling.pdf"/> </rdf:Description> </rdf:RDF>

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