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TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis

TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis

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Prüfsumme: MD5:92a14a2409d2202b8638e7c4b1e9e156

NOTI, Mario, Nadia CORAZZA, Christoph MÜLLER, Barbara BERGER, Thomas BRUNNER, 2010. TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis. In: The journal of experimental medicine. 207(5), pp. 1057-1066. ISSN 0022-1007. eISSN 1540-9538. Available under: doi: 10.1084/jem.20090849

@article{Noti2010suppr-8664, title={TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis}, year={2010}, doi={10.1084/jem.20090849}, number={5}, volume={207}, issn={0022-1007}, journal={The journal of experimental medicine}, pages={1057--1066}, author={Noti, Mario and Corazza, Nadia and Müller, Christoph and Berger, Barbara and Brunner, Thomas} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8664"> <dc:creator>Müller, Christoph</dc:creator> <dcterms:bibliographicCitation>First publ. in: The journal of experimental medicine 207 (2010), 5, pp. 1057-1066</dcterms:bibliographicCitation> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:language>eng</dc:language> <dc:rights>deposit-license</dc:rights> <dcterms:issued>2010</dcterms:issued> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Corazza, Nadia</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Corazza, Nadia</dc:creator> <dc:contributor>Müller, Christoph</dc:contributor> <dc:creator>Berger, Barbara</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8664"/> <dcterms:title>TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis</dcterms:title> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:45:31Z</dcterms:available> <dc:contributor>Noti, Mario</dc:contributor> <dc:contributor>Berger, Barbara</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:45:31Z</dc:date> <dc:contributor>Brunner, Thomas</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8664/1/2010_TNF_Edit.pdf"/> <dcterms:abstract xml:lang="eng">Although tumor necrosis factor (Alpha) (TNF) exerts proinflammatory activities in a variety of diseases, including inflammatory bowel disease, there is increasing evidence for antiinflammatory actions of TNF. In contrast, glucocorticoids (GCs) are steroid hormones that suppress inflammation, at least in part by regulating the expression and action of TNF. We report that TNF induces extraadrenal production of immunoregulatory GCs in the intestinal mucosa during acute intestinal inflammation. The absence of TNF results in a lack of colonic GC synthesis and exacerbation of dextran sodium sulfate induced colitis. TNF seems to promote local steroidogenesis by directly inducing steroidogenic enzymes in intestinal epithelial cells. Therapeutic administration of TNF induces GC synthesis in oxazoloneinduced colitis and ameliorates intestinal inflammation, whereas inhibition of intestinal GC synthesis abrogates the therapeutic effect of TNF. These data show that TNF suppresses the pathogenesis of acute intestinal inflammation by promoting local steroidogenesis.</dcterms:abstract> <dc:creator>Noti, Mario</dc:creator> <dc:format>application/pdf</dc:format> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8664/1/2010_TNF_Edit.pdf"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Brunner, Thomas</dc:creator> </rdf:Description> </rdf:RDF>

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