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Major events in the genome evolution of vertebrates : paranome age and size differ considerably between ray-finned fishes and land vertebrates

Major events in the genome evolution of vertebrates : paranome age and size differ considerably between ray-finned fishes and land vertebrates

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VANDEPOELE, Klaas, Wouter de VOS, John S. TAYLOR, Axel MEYER, Yves VAN DER PEER, 2004. Major events in the genome evolution of vertebrates : paranome age and size differ considerably between ray-finned fishes and land vertebrates. In: Proceedings of the National Academy of Sciences. 101(6), pp. 1638-1643. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.0307968100

@article{Vandepoele2004-02-10Major-8648, title={Major events in the genome evolution of vertebrates : paranome age and size differ considerably between ray-finned fishes and land vertebrates}, year={2004}, doi={10.1073/pnas.0307968100}, number={6}, volume={101}, issn={0027-8424}, journal={Proceedings of the National Academy of Sciences}, pages={1638--1643}, author={Vandepoele, Klaas and Vos, Wouter de and Taylor, John S. and Meyer, Axel and Van der Peer, Yves} }

2011-03-24T17:45:23Z Vandepoele, Klaas Van der Peer, Yves Vos, Wouter de Vandepoele, Klaas Taylor, John S. Meyer, Axel Van der Peer, Yves eng deposit-license Taylor, John S. First publ. in: Proceedings of the National Academy of Science, 101 (2004), 6, pp. 1638-1643 2004-02-10 Major events in the genome evolution of vertebrates : paranome age and size differ considerably between ray-finned fishes and land vertebrates Meyer, Axel 2011-03-24T17:45:23Z Vos, Wouter de application/pdf It has been suggested that fish have more genes than humans. Whether most of these additional genes originated through a complete (fish-specific) genome duplication or through many lineagespecific tandem gene or smaller block duplications and family expansions continues to be debated. We analyzed the complete genome of the pufferfish Takifugu rubripes (Fugu) and compared it with the paranome of humans. We show that most paralogous genes of Fugu are the result of three complete genome duplications. Both relative and absolute dating of the complete predicted set of protein-coding genes suggest that initial genome duplications, estimated to have occurred at least 600 million years ago, shaped the genome of all vertebrates. In addition, analysis of >150 block duplications in the Fugu genome clearly supports a fish-specific genome muplication (320 million years ago) that coincided with the vast radiation of most modern ray-finned fishes. Unlike the human genome, Fugu contains very few recently duplicated genes; hence, many human genes are much younger than fish genes. This lack of recent gene duplication, or, alternatively, the accelerated rate of gene loss, is possibly one reason for the drastic reduction of the genome size of Fugu observed during the past 100 million years or so, subsequent to the additional genome duplication that ray-finned fishes but not land vertebrates experienced.

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