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ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha

ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha

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Prüfsumme: MD5:e41c116f0fc216444933c292d6d6f893

KÜNSTLE, Gerald, Marcel LEIST, Stefan UHLIG, Laszlo REVESZ, Roland FEIFEL, Andrew MACKENZIE, Albrecht WENDEL, 1997. ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha. In: Immunology Letters. 55(1), pp. 5-10. ISSN 1879-0542. eISSN 0165-2478

@article{Kunstle1997ICE-p-8645, title={ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha}, year={1997}, number={1}, volume={55}, issn={1879-0542}, journal={Immunology Letters}, pages={5--10}, author={Künstle, Gerald and Leist, Marcel and Uhlig, Stefan and Revesz, Laszlo and Feifel, Roland and MacKenzie, Andrew and Wendel, Albrecht} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8645"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:45:21Z</dc:date> <dc:format>application/pdf</dc:format> <dcterms:bibliographicCitation>Immunology Letters ; 55 (1997), 1. - S. 5-10</dcterms:bibliographicCitation> <dc:creator>Wendel, Albrecht</dc:creator> <dcterms:abstract xml:lang="eng">The two apoptosis receptors of mammalian cells, i.e. the 55 kDa TNF receptor (TNF-R1) and CD95 (Fas/APO1) are activated independently of each other, however, their signaling involves a variety of ICE-related proteases. We used a cell-permeable inhibitor of ICE-like protease activity to examine in vivo whether post-receptor signaling of TNF and CD95 are fully independent processes. Mice pretreated with the inhibitor, Z-VAD-fluoromethylketone (FMK) were dose-dependently protected from liver injury caused by CD95 activation as determined by plasma alanine aminotransferase and also from hepatocyte apoptosis assessed by DNA fragmentation (ID50=0.1 mg/kg). A dose of 10 mg/kg protected mice also from liver injury induced by TNF-α. Similar results were found when apoptosis was initiated via TNF-α or via CD95 in primary murine hepatocytes (IC50=1.5 nM) or in various human cell lines. In addition to prevention, an arrest of cell death by Z-VAD-FMK was demonstrated in vivo and in vitro after stimulation of apoptosis receptors. These findings show in vitro and in vivo in mammals that CD95 and the TNF-α receptor share a distal proteolytic apoptosis signal.</dcterms:abstract> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:45:21Z</dcterms:available> <dc:creator>Feifel, Roland</dc:creator> <dc:language>eng</dc:language> <dc:contributor>MacKenzie, Andrew</dc:contributor> <dc:creator>Leist, Marcel</dc:creator> <dc:creator>MacKenzie, Andrew</dc:creator> <dc:contributor>Uhlig, Stefan</dc:contributor> <dc:creator>Künstle, Gerald</dc:creator> <dc:creator>Revesz, Laszlo</dc:creator> <dc:contributor>Revesz, Laszlo</dc:contributor> <dc:contributor>Leist, Marcel</dc:contributor> <dc:contributor>Künstle, Gerald</dc:contributor> <dc:contributor>Wendel, Albrecht</dc:contributor> <dcterms:issued>1997</dcterms:issued> <dc:creator>Uhlig, Stefan</dc:creator> <dc:rights>deposit-license</dc:rights> <dcterms:title>ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha</dcterms:title> <dc:contributor>Feifel, Roland</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8645"/> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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