Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1

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BENEKE, Sascha, Odile COHAUSZ, Maria MALANGA, Petra BOUKAMP, Felix ALTHAUS, Alexander BÜRKLE, 2008. Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1. In: Nucleic Acids Research. 36(19), pp. 6309-6317. ISSN 0305-1048. eISSN 1362-4962

@article{Beneke2008Rapid-8586, title={Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1}, year={2008}, doi={10.1093/nar/gkn615}, number={19}, volume={36}, issn={0305-1048}, journal={Nucleic Acids Research}, pages={6309--6317}, author={Beneke, Sascha and Cohausz, Odile and Malanga, Maria and Boukamp, Petra and Althaus, Felix and Bürkle, Alexander} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8586"> <dc:contributor>Cohausz, Odile</dc:contributor> <dcterms:issued>2008</dcterms:issued> <dc:contributor>Boukamp, Petra</dc:contributor> <dc:rights>deposit-license</dc:rights> <dc:contributor>Beneke, Sascha</dc:contributor> <dcterms:bibliographicCitation>First publ. in: Nucleic Acids Research, 36 (2008), 19, pp. 6309-6317</dcterms:bibliographicCitation> <dc:creator>Althaus, Felix</dc:creator> <dc:creator>Boukamp, Petra</dc:creator> <dcterms:abstract xml:lang="eng">Shelterin/telosome is a multi-protein complex at mammalian telomeres, anchored to the double-stranded region by the telomeric-repeat binding factors-1 and -2. In vitro modification of these proteins by poly(ADP-ribosyl)ation through poly(ADP-ribose) polymerases-5 (tankyrases) and -1/-2, respectively, impairs binding. Thereafter, at least telomeric-repeat binding factor-1 is degraded by the proteasome. We show that pharmacological inhibition of poly(ADP-ribose) polymerase activity in cells from two different species leads to rapid decrease in median telomere length and stabilization at a lower setting. Specific knockdown of poly(ADP-ribose) polymerase-1 by RNA interference had the same effect. The length of the single-stranded telomeric overhang as well as telomerase activity were not affected. Release of inhibition led to a fast re-gain in telomere length to control levels in cells expressing active telomerase. We conclude that poly(ADP-ribose) polymerase-1 activity and probably its interplay with telomeric-repeat binding factor-2 is an important determinant in telomere regulation. Our findings reinforce the link between poly(ADP-ribosyl)ation and aging/longevity and also impact on the use of poly(ADP-ribose) polymerase inhibitors in tumor therapy.</dcterms:abstract> <dc:language>eng</dc:language> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:44:53Z</dc:date> <dc:creator>Cohausz, Odile</dc:creator> <dc:creator>Malanga, Maria</dc:creator> <dcterms:title>Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1</dcterms:title> <dc:creator>Bürkle, Alexander</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:contributor>Malanga, Maria</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:44:53Z</dcterms:available> <dc:creator>Beneke, Sascha</dc:creator> <dc:contributor>Bürkle, Alexander</dc:contributor> <dc:format>application/pdf</dc:format> <dc:contributor>Althaus, Felix</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8586"/> </rdf:Description> </rdf:RDF>

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