@article{Beneke2008Rapid-8586,
  year={2008},
  doi={10.1093/nar/gkn615},
  title={Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1},
  number={19},
  volume={36},
  issn={0305-1048},
  journal={Nucleic Acids Research},
  pages={6309--6317},
  author={Beneke, Sascha and Cohausz, Odile and Malanga, Maria and Boukamp, Petra and Althaus, Felix and Bürkle, Alexander}
}

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    <dcterms:title>Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1</dcterms:title>
    <dcterms:abstract xml:lang="eng">Shelterin/telosome is a multi-protein complex at mammalian telomeres, anchored to the double-stranded region by the telomeric-repeat binding factors-1 and -2. In vitro modification of these proteins by poly(ADP-ribosyl)ation through poly(ADP-ribose) polymerases-5 (tankyrases) and -1/-2, respectively, impairs binding. Thereafter, at least telomeric-repeat binding factor-1 is degraded by the proteasome. We show that pharmacological inhibition of poly(ADP-ribose) polymerase activity in cells from two different species leads to rapid decrease in median telomere length and stabilization at a lower setting. Specific knockdown of poly(ADP-ribose) polymerase-1 by RNA interference had the same effect. The length of the single-stranded telomeric overhang as well as telomerase activity were not affected. Release of inhibition led to a fast re-gain in telomere length to control levels in cells expressing active telomerase. We conclude that poly(ADP-ribose) polymerase-1 activity and probably its interplay with telomeric-repeat binding factor-2 is an important determinant in telomere regulation. Our findings reinforce the link between poly(ADP-ribosyl)ation and aging/longevity and also impact on the use of poly(ADP-ribose) polymerase inhibitors in tumor therapy.</dcterms:abstract>
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    <dc:contributor>Beneke, Sascha</dc:contributor>
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    <dc:creator>Beneke, Sascha</dc:creator>
    <dc:contributor>Malanga, Maria</dc:contributor>
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    <dc:creator>Boukamp, Petra</dc:creator>
    <dcterms:bibliographicCitation>First publ. in: Nucleic Acids Research, 36 (2008), 19, pp. 6309-6317</dcterms:bibliographicCitation>
    <dc:creator>Althaus, Felix</dc:creator>
    <dc:creator>Bürkle, Alexander</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:44:53Z</dc:date>
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    <dc:contributor>Boukamp, Petra</dc:contributor>
    <dc:creator>Cohausz, Odile</dc:creator>
    <dcterms:issued>2008</dcterms:issued>
    <dc:contributor>Cohausz, Odile</dc:contributor>
    <dc:creator>Malanga, Maria</dc:creator>
    <dc:contributor>Bürkle, Alexander</dc:contributor>
    <dc:contributor>Althaus, Felix</dc:contributor>
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