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The re-establishment of synaptic transmission by regenerating optic axons in goldfish : time course and effects of blocking activity by intraocular injection of tetrodotoxin

The re-establishment of synaptic transmission by regenerating optic axons in goldfish : time course and effects of blocking activity by intraocular injection of tetrodotoxin

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SCHMIDT, John T., D. L. EDWARDS, Claudia STÜRMER, 1983. The re-establishment of synaptic transmission by regenerating optic axons in goldfish : time course and effects of blocking activity by intraocular injection of tetrodotoxin. In: Brain Research. 269(1), pp. 15-27. ISSN 0006-8993

@article{Schmidt1983re-es-8584, title={The re-establishment of synaptic transmission by regenerating optic axons in goldfish : time course and effects of blocking activity by intraocular injection of tetrodotoxin}, year={1983}, doi={10.1016/0006-8993(83)90958-7}, number={1}, volume={269}, issn={0006-8993}, journal={Brain Research}, pages={15--27}, author={Schmidt, John T. and Edwards, D. L. and Stürmer, Claudia} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8584"> <dcterms:title>The re-establishment of synaptic transmission by regenerating optic axons in goldfish : time course and effects of blocking activity by intraocular injection of tetrodotoxin</dcterms:title> <dc:creator>Edwards, D. L.</dc:creator> <dc:contributor>Edwards, D. L.</dc:contributor> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:language>eng</dc:language> <dcterms:issued>1983</dcterms:issued> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:44:52Z</dc:date> <dc:rights>deposit-license</dc:rights> <dc:contributor>Schmidt, John T.</dc:contributor> <dc:creator>Stürmer, Claudia</dc:creator> <dcterms:bibliographicCitation>First publ. in: Brain Research 269 (1983), pp. 15-27</dcterms:bibliographicCitation> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8584"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:44:52Z</dcterms:available> <dc:contributor>Stürmer, Claudia</dc:contributor> <dc:creator>Schmidt, John T.</dc:creator> <dcterms:abstract xml:lang="eng">Intraocular injections of tetrodotoxin were used to block activity for 27 days in normal fish and for the first 27 or 31 days of regeneration in fish with one optic nerve crushed. Synaptic activity was then assessed by a current source-density analysis of field potentials evoked by optic nerve shock at different times following the TTX treatment. In normal fish, the lack of activity for 4 weeks had no significant effect on the maintenance of synaptic strength. Likewise, in fish with nerve crush, lack of activity did not prevent the regenerating optic fibers from forming synapses that were nearly as effective as those formed in controls injected with the citrate buffer vehicle. The earliest synapses were formed at the rostromedial corner of the tectum (where the tract enters) at 20 days after nerve crush, when fibers had not yet reached the caudal areas. By 28 days synaptic potentials could be recorded everywhere on the surface of the tectum in both controls and TTX injected fish. However, the latency of the responseswith TTX were longer, suggesting a smaller caliber of fiber, which is consistent with an earlier finding of decreased axonal transport in TTX fish6. Maturation of the regenerating fibers proceeded slowly in both TTX and control fish. After more than 5 months, the projections were nearly normal but still not completely normal.</dcterms:abstract> <dc:format>application/pdf</dc:format> </rdf:Description> </rdf:RDF>

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