KOPS - Das Institutionelle Repositorium der Universität Konstanz

Drosophila GoLoco-Protein Pins is a target of G{alpha}o-mediated G Protein-coupled Receptor Signaling

Drosophila GoLoco-Protein Pins is a target of G{alpha}o-mediated G Protein-coupled Receptor Signaling

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:a74be8530542ddbe0bdd7f739c23b736

KOPEIN, Damir, Vladimir L. KATANAEV, 2009. Drosophila GoLoco-Protein Pins is a target of G{alpha}o-mediated G Protein-coupled Receptor Signaling. In: Molecular Biology of the Cell. 20(17), pp. 3865-3877. ISSN 1059-1524. eISSN 1939-4586

@article{Kopein2009Droso-8541, title={Drosophila GoLoco-Protein Pins is a target of G{alpha}o-mediated G Protein-coupled Receptor Signaling}, year={2009}, number={17}, volume={20}, issn={1059-1524}, journal={Molecular Biology of the Cell}, pages={3865--3877}, author={Kopein, Damir and Katanaev, Vladimir L.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8541"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:44:31Z</dc:date> <dcterms:title>Drosophila GoLoco-Protein Pins is a target of G{alpha}o-mediated G Protein-coupled Receptor Signaling</dcterms:title> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:44:31Z</dcterms:available> <dcterms:issued>2009</dcterms:issued> <dc:contributor>Katanaev, Vladimir L.</dc:contributor> <dc:format>application/pdf</dc:format> <dc:creator>Kopein, Damir</dc:creator> <dc:contributor>Kopein, Damir</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8541"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Katanaev, Vladimir L.</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8541/1/Drosophila_GoLoco_Protein_Pins_is_a_target_of_Galphao_mediated_G_Protein_coupled_Receptor_Signaling.pdf"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8541/1/Drosophila_GoLoco_Protein_Pins_is_a_target_of_Galphao_mediated_G_Protein_coupled_Receptor_Signaling.pdf"/> <dc:rights>deposit-license</dc:rights> <dcterms:bibliographicCitation>First publ. in: Molecular Biology of the Cell 20 (2009), 17, pp. 3865-3877</dcterms:bibliographicCitation> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:language>eng</dc:language> <dcterms:abstract xml:lang="eng">G protein-coupled receptors (GPCRs) transduce their signals through trimeric G proteins, inducing guanine nucleotide exchange on their Galpha-subunits; the resulting Galpha-GTP transmits the signal further inside the cell. GoLoco domains present in many proteins play important roles in multiple trimeric G protein-dependent activities, physically binding Galpha-subunits of the Galphai/o class. In most cases GoLoco binds exclusively to the GDP-loaded form of the Galpha-subunits. Here we demonstrate that the poly-GoLoco-containing protein Pins of Drosophila can bind to both GDP- and GTP-forms of Drosophila Galphao. We identify Pins GoLoco domain 1 as necessary and sufficient for this unusual interaction with Galphao-GTP. We further pinpoint a Lysine residue located centrally in this domain as necessary for the interaction. Our studies thus identify Drosophila Pins as a target of Galphao-mediated GPCR receptor signaling, e.g., in the context of the nervous system development, where Galphao acts downstream from Frizzled and redundantly with Galphai to control the asymmetry of cell divisions.</dcterms:abstract> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Drosophila_GoLoco_Protein_Pins_is_a_target_of_Galphao_mediated_G_Protein_coupled_Receptor_Signaling.pdf 145

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto