KOPS - The Institutional Repository of the University of Konstanz

Neurolin Ig Domain 2 Participates in Retinal Axon Guidance and Ig Domains 1 and 3 in Fasciculation

Aufgrund von Vorbereitungen auf eine neue Version von KOPS, können kommenden Montag und Dienstag keine Publikationen eingereicht werden. (Due to preparations for a new version of KOPS, no publications can be submitted next Monday and Tuesday.)

Neurolin Ig Domain 2 Participates in Retinal Axon Guidance and Ig Domains 1 and 3 in Fasciculation

Cite This

Files in this item

Checksum: MD5:d78141169ebf59bf61fe513754685d72

LEPPERT, Christian A., Heike DIEKMANN, Claudia PAUL, Ute LAESSING, Monika MARX, Martin BASTMEYER, Claudia STÜRMER, 1999. Neurolin Ig Domain 2 Participates in Retinal Axon Guidance and Ig Domains 1 and 3 in Fasciculation. In: Journal of Cell Biology. 144(2), pp. 339-349. ISSN 0021-9525. eISSN 1540-8140

@article{Leppert1999Neuro-8499, title={Neurolin Ig Domain 2 Participates in Retinal Axon Guidance and Ig Domains 1 and 3 in Fasciculation}, year={1999}, number={2}, volume={144}, issn={0021-9525}, journal={Journal of Cell Biology}, pages={339--349}, author={Leppert, Christian A. and Diekmann, Heike and Paul, Claudia and Laessing, Ute and Marx, Monika and Bastmeyer, Martin and Stürmer, Claudia} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8499"> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:title>Neurolin Ig Domain 2 Participates in Retinal Axon Guidance and Ig Domains 1 and 3 in Fasciculation</dcterms:title> <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8499/1/Neurolin_Ig_domain.pdf"/> <dc:creator>Marx, Monika</dc:creator> <dc:contributor>Laessing, Ute</dc:contributor> <dc:contributor>Paul, Claudia</dc:contributor> <dc:creator>Diekmann, Heike</dc:creator> <dc:creator>Bastmeyer, Martin</dc:creator> <dc:creator>Laessing, Ute</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Leppert, Christian A.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:44:10Z</dcterms:available> <dc:contributor>Leppert, Christian A.</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8499/1/Neurolin_Ig_domain.pdf"/> <dc:contributor>Stürmer, Claudia</dc:contributor> <dcterms:abstract xml:lang="eng">The optic diskÐdirected growth of retinal ganglion cell axons is markedly disturbed in the presence of polyclonal antineurolin antibodies, which mildly affect fasciculation. New monoclonal antibodies (mAbs) against goldfish neurolin, an immunoglobulin (Ig) superfamily cell adhesion/ recognition molecule with five Ig domains, were generated to assign function (guidance versus fasciculation) to specific Ig domains. By their ability or failure to recognize Chinese hamster ovary cells expressing recombinant neurolin with deletions of defined Ig domains, mAbs were identified as being directed against Ig domains 1, 2, or 3, respectively. Repeated intraocular injections of a mAb against Ig domain 2 disturb the disk-directed growth: axons grow in aberrant routes and fail to reach the optic disk, but remain fasciculated. mAbs against Ig domains 1 and 3 disturb the formation of tight fascicles. mAb against Ig domain 2 significantly increases the incidence of growth cone departure from the disk-oriented fascicle track, while mAbs against Ig domains 1 and 3 do not. This was demonstrated by time-lapse videorecording of labeled growth cones. Thus, Ig domain 2 of neurolin is apparently essential for growth cone guidance towards the disk, presumably by being part of a receptor (or complex) for an axon guidance component.</dcterms:abstract> <dc:contributor>Marx, Monika</dc:contributor> <dc:contributor>Diekmann, Heike</dc:contributor> <dcterms:issued>1999</dcterms:issued> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:44:10Z</dc:date> <dc:creator>Stürmer, Claudia</dc:creator> <dc:creator>Paul, Claudia</dc:creator> <dc:contributor>Bastmeyer, Martin</dc:contributor> <dc:language>eng</dc:language> <dc:format>application/pdf</dc:format> <dcterms:bibliographicCitation>First publ. in: Journal of Cell Biology 144 (1999), 2, pp. 339-349</dcterms:bibliographicCitation> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8499"/> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> </rdf:Description> </rdf:RDF>

Downloads since Oct 1, 2014 (Information about access statistics)

Neurolin_Ig_domain.pdf 413

This item appears in the following Collection(s)

Attribution-NonCommercial-NoDerivs 2.0 Generic Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 2.0 Generic

Search KOPS


My Account