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Mechanisms of cell death induction by L-amino acid oxidase, a major component of ophidian venom

Mechanisms of cell death induction by L-amino acid oxidase, a major component of ophidian venom

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ANDE, Sudharsana Rao, Phaneeswara Rao KOMMOJU, Sigrid DRAXL, Michael MURKOVIC, Peter MACHEROUX, Sandro GHISLA, Elisa MAY, 2006. Mechanisms of cell death induction by L-amino acid oxidase, a major component of ophidian venom. In: Apoptosis. 11(8), pp. 1439-1451. ISSN 1360-8185. eISSN 1573-675X

@article{Ande2006Mecha-8420, title={Mechanisms of cell death induction by L-amino acid oxidase, a major component of ophidian venom}, year={2006}, doi={10.1007/s10495-006-7959-9}, number={8}, volume={11}, issn={1360-8185}, journal={Apoptosis}, pages={1439--1451}, author={Ande, Sudharsana Rao and Kommoju, Phaneeswara Rao and Draxl, Sigrid and Murkovic, Michael and Macheroux, Peter and Ghisla, Sandro and May, Elisa} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8420"> <dc:rights>deposit-license</dc:rights> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:contributor>Macheroux, Peter</dc:contributor> <dc:creator>Ande, Sudharsana Rao</dc:creator> <dc:contributor>May, Elisa</dc:contributor> <dc:creator>Murkovic, Michael</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:43:28Z</dc:date> <dc:contributor>Ande, Sudharsana Rao</dc:contributor> <dc:contributor>Kommoju, Phaneeswara Rao</dc:contributor> <dcterms:title>Mechanisms of cell death induction by L-amino acid oxidase, a major component of ophidian venom</dcterms:title> <dc:contributor>Draxl, Sigrid</dc:contributor> <dc:creator>May, Elisa</dc:creator> <dc:contributor>Murkovic, Michael</dc:contributor> <dc:format>application/pdf</dc:format> <dc:contributor>Ghisla, Sandro</dc:contributor> <dcterms:abstract xml:lang="eng">L-amino acid oxidase (LAAO) from the Malayan pit viper induces both necrosis and apoptosis in Jurkat cells. Cell death by necrosis is attributed to H2O2 produced by oxidation of α-amino acids. In the presence of catalase that effectively scavenges H2O2, a switch to apoptosis is observed. The major factors contributing to apoptosis are proposed to be: (i) generation of toxic intermediates from fetal calf serum (ii) binding and internalization of LAAO. The latter process appears to be mediated by the glycan moiety of the enzyme as desialylation reduces cytotoxicity. D-amino acid oxidase (DAAO), which catalyzes the same reaction as LAAO but lacks glycosylation, triggers necrosis as a consequence of H2O2 production but not apoptosis in the presence of catalase. Thus induction of cell death by LAAO appears to involve both the generation of H2O2 and the molecular interaction of the glycan moiety of the enzyme with structures at the cell surface.</dcterms:abstract> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8420"/> <dc:creator>Draxl, Sigrid</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:43:28Z</dcterms:available> <dc:creator>Macheroux, Peter</dc:creator> <dc:creator>Kommoju, Phaneeswara Rao</dc:creator> <dcterms:issued>2006</dcterms:issued> <dc:language>eng</dc:language> <dcterms:bibliographicCitation>First publ. in: Apoptosis 11 (2006), 8, pp. 1439-1451</dcterms:bibliographicCitation> <dc:creator>Ghisla, Sandro</dc:creator> </rdf:Description> </rdf:RDF>

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