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CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria induced detachment of epithelial cells

CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria induced detachment of epithelial cells

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Prüfsumme: MD5:8ce1b9a3f388506a430284280cac2f75

MUENZNER, Petra, Manfred ROHDE, Susanne KNEITZ, Christof R. HAUCK, 2005. CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria induced detachment of epithelial cells. In: Journal of Cell Biology. 170(5), pp. 825-836. ISSN 0021-9525. eISSN 1540-8140

@article{Muenzner2005CEACA-8341, title={CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria induced detachment of epithelial cells}, year={2005}, doi={10.1083/jcb.200412151}, number={5}, volume={170}, issn={0021-9525}, journal={Journal of Cell Biology}, pages={825--836}, author={Muenzner, Petra and Rohde, Manfred and Kneitz, Susanne and Hauck, Christof R.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8341"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:42:48Z</dc:date> <dc:contributor>Rohde, Manfred</dc:contributor> <dc:contributor>Hauck, Christof R.</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Muenzner, Petra</dc:contributor> <dc:creator>Rohde, Manfred</dc:creator> <dcterms:bibliographicCitation>First publ. in: Journal of Cell Biology 170 (2005), 5, pp. 825 836</dcterms:bibliographicCitation> <dc:creator>Hauck, Christof R.</dc:creator> <dc:creator>Kneitz, Susanne</dc:creator> <dc:creator>Muenzner, Petra</dc:creator> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dcterms:issued>2005</dcterms:issued> <dc:format>application/pdf</dc:format> <dc:rights>deposit-license</dc:rights> <dc:contributor>Kneitz, Susanne</dc:contributor> <dcterms:title>CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria induced detachment of epithelial cells</dcterms:title> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8341"/> <dcterms:abstract xml:lang="eng">Exfoliation, which is the detachment of infected epithelial cells, is an innate defense mechanism to prevent bacterial colonization. Indeed, infection with Neisseria gonorrhoeae induced epithelial detachment from an extracellular matrix (ECM) substrate in vitro. Surprisingly, variants of N. gonorrhoeae that bind to human carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) failed to induce detachment and, instead, promoted enhanced host cell adhesion to the ECM. Microarray analysis revealed that CEACAM engagement by several human pathogens triggers expression of CD105. Blockage of CD105 expression by antisense oligonucleotides abolished infection-induced cell adhesion. The expression of full-length CD105 promoted cell adhesion to the ECM and was sufficient to prevent infection-induced detachment. The CD105-mediated increase in cell adhesion was dependent on the presence and function of integrin ß1. CD105 expression did not elevate cellular integrin levels but caused a dramatic increase in the ECM-binding capacity of the cells, suggesting that CD105 affects integrin activity. The exploitation of CEACAMs to trigger CD105 expression and to counteract infection-induced cell detachment represents an intriguing adaptation of pathogens that are specialized to colonize the human mucosa.</dcterms:abstract> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:42:48Z</dcterms:available> </rdf:Description> </rdf:RDF>

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