KOPS - Das Institutionelle Repositorium der Universität Konstanz

Folding kinetics of the outer membrane proteins OmpA and FomA into phospholipid bilayers

Folding kinetics of the outer membrane proteins OmpA and FomA into phospholipid bilayers

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:ed079897c86ac0e3e11da97470efad15

KLEINSCHMIDT, Jörg H., 2006. Folding kinetics of the outer membrane proteins OmpA and FomA into phospholipid bilayers. In: Chemistry and Physics of Lipids. 141(1-2), pp. 30-47. ISSN 0009-3084. Available under: doi: 10.1016/j.chemphyslip.2006.02.004

@article{Kleinschmidt2006Foldi-8329, title={Folding kinetics of the outer membrane proteins OmpA and FomA into phospholipid bilayers}, year={2006}, doi={10.1016/j.chemphyslip.2006.02.004}, number={1-2}, volume={141}, issn={0009-3084}, journal={Chemistry and Physics of Lipids}, pages={30--47}, author={Kleinschmidt, Jörg H.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8329"> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:language>eng</dc:language> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8329/1/Folding_kinetics_of_the_outer_membrane_proteins_OmpA_and_FomA_into_phospholipid_bilayers.pdf"/> <dc:rights>deposit-license</dc:rights> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8329/1/Folding_kinetics_of_the_outer_membrane_proteins_OmpA_and_FomA_into_phospholipid_bilayers.pdf"/> <dc:format>application/pdf</dc:format> <dcterms:abstract xml:lang="eng">The folding mechanism of outer membrane proteins (OMPs) of Gram-negative bacteria into lipid bilayers has been studied using OmpA of E.coli and FomA of F.nucleatum as examples. Both, OmpA and FomA are soluble in unfolded form in urea and insert and fold into phospholipid bilayers upon strong dilution of the denaturant urea. OmpAis a structural protein and forms a small ion channel, composed of an 8-stranded transmembrane β-barrel domain. FomA is a voltage-dependent porin, predicted to form a 14 stranded β-barrel. Both OMPs fold into a range of model membranes of very different phospholipid compositions. Three membrane-bound folding intermediates of OmpA were discovered in folding studies with dioleoylphosphatidylcholine bilayers that demonstrated a highly synchronized mechanism of secondary and tertiary structure formation of β-barrel membrane proteins. A study on FomA folding into lipid bilayers indicated the presence of parallel folding pathways for OMPs with larger transmembrane β-barrels.</dcterms:abstract> <dc:contributor>Kleinschmidt, Jörg H.</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:42:43Z</dc:date> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:bibliographicCitation>First publ. in: Chemistry and Physics of Lipids 141 (2006), 1-2, pp. 30-47</dcterms:bibliographicCitation> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:42:43Z</dcterms:available> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8329"/> <dcterms:title>Folding kinetics of the outer membrane proteins OmpA and FomA into phospholipid bilayers</dcterms:title> <dc:creator>Kleinschmidt, Jörg H.</dc:creator> <dcterms:issued>2006</dcterms:issued> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Folding_kinetics_of_the_outer_membrane_proteins_OmpA_and_FomA_into_phospholipid_bilayers.pdf 149

Das Dokument erscheint in:

deposit-license Solange nicht anders angezeigt, wird die Lizenz wie folgt beschrieben: deposit-license

KOPS Suche


Stöbern

Mein Benutzerkonto