MDP and other muropeptides : direct and synergistic effects on the immune system


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TRAUB, Stephanie, Sonja von AULOCK, Thomas HARTUNG, Corinna HERMANN, 2006. MDP and other muropeptides : direct and synergistic effects on the immune system. In: Journal of endotoxin research. 12(2), pp. 69-85. Available under: doi: 10.1177/09680519060120020301

@article{Traub2006other-8318, title={MDP and other muropeptides : direct and synergistic effects on the immune system}, year={2006}, doi={10.1177/09680519060120020301}, number={2}, volume={12}, journal={Journal of endotoxin research}, pages={69--85}, author={Traub, Stephanie and Aulock, Sonja von and Hartung, Thomas and Hermann, Corinna} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:format>application/pdf</dc:format> <dcterms:title>MDP and other muropeptides : direct and synergistic effects on the immune system</dcterms:title> <dcterms:issued>2006</dcterms:issued> <dc:creator>Hermann, Corinna</dc:creator> <dc:date rdf:datatype="">2011-03-24T17:42:38Z</dc:date> <bibo:uri rdf:resource=""/> <dc:creator>Hartung, Thomas</dc:creator> <dcterms:hasPart rdf:resource=""/> <dspace:hasBitstream rdf:resource=""/> <dcterms:bibliographicCitation>First publ. in: Journal of endotoxin research 12 (2006), 2, pp. 69-85</dcterms:bibliographicCitation> <dc:language>eng</dc:language> <dspace:isPartOfCollection rdf:resource=""/> <dc:creator>Traub, Stephanie</dc:creator> <dcterms:available rdf:datatype="">2011-03-24T17:42:38Z</dcterms:available> <dcterms:isPartOf rdf:resource=""/> <dc:creator>Aulock, Sonja von</dc:creator> <dcterms:rights rdf:resource=""/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:abstract xml:lang="eng">Muropeptides are breakdown products of peptidoglycan (PGN) of Gram-negative and Gram-positive bacteria. They are released during bacterial growth and division, as part of the host response by lysozyme and amidases, or upon antibiotic treatment. After phagocytosis of bacteria or bacterial breakdown products by host immune cells, the muropeptides trigger intracellular signaling cascades, leading to altered gene expression and activation of the immune response. Numerous muropeptides and derivatives have been synthesized chemically to characterize their immunostimulatory effects and adjuvant activity. Muramyl dipeptide, a natural partial structure of PGN, is the minimal structure with adjuvant activity. This review discusses the structure and occurrence of muropeptides and gives a broad overview of their inflammatory and adjuvant activity and the possible involvement of receptors in these responses.</dcterms:abstract> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Hartung, Thomas</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Traub, Stephanie</dc:contributor> <dc:contributor>Hermann, Corinna</dc:contributor> <dc:contributor>Aulock, Sonja von</dc:contributor> </rdf:Description> </rdf:RDF>

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