Blood cytokine response of low-dose molgramostim (rhGM-CSF)-treated patients

Hartung, Thomas; Aulock, Sonja von; Freitag, Marcus; Höxtermann, Stefan; Stücker, Markus; Hoffmann, Klaus; Altmeyer, Peter; Kottke, Andrea; Wendel, Albrecht

Blood cytokine response of low-dose molgramostim (rhGM-CSF)-treated patients

Files

2000HartungCytok_bearb.pdf(7.4 MB)

Date

2000

Authors

Hartung, Thomas

Aulock, Sonja von

Freitag, Marcus

Höxtermann, Stefan

Stücker, Markus

Hoffmann, Klaus

Altmeyer, Peter

Kottke, Andrea

Wendel, Albrecht

Publication type

Journal article

Published in

Cytokine ; 12 (2000), 10. - pp. 1570-1574. - ISSN 1043-4666

Abstract

We examined leukocyte counts and ex vivo cytokine response of whole blood to lipopolysaccharide (LPS) or lipoteichoic acid (LTA) in patients under low-dose molgramostim therapy. Patients were injected subcutaneously daily for ten days with 1 μg/kg (n=9) or 2 μg/kg (n=14) molgramostim. Leukocytosis was observed in all patients, but only the eosinophil fraction was significantly increased in relation to other leukocyte populations. Ex vivo IFN-γ release was decreased and IL-10 and IL-1ra secretion were increased in response to LPS or LTA. Thus, in non-neutropenic patients, leukocytosis can already be initiated by low doses of molgramostim. The ex vivo cytokine data suggest that these doses prime blood towards a systemic anti-inflammatory response.

Subject (DDC)

570 Biosciences, Biology

Keywords

blood,cytokines,growth factors,human,inflammation

Cite This

ISO 690

HARTUNG, Thomas, Sonja von AULOCK, Marcus FREITAG, Stefan HÖXTERMANN, Markus STÜCKER, Klaus HOFFMANN, Peter ALTMEYER, Andrea KOTTKE, Albrecht WENDEL, 2000. Blood cytokine response of low-dose molgramostim (rhGM-CSF)-treated patients. In: Cytokine. 12(10), pp. 1570-1574. ISSN 1043-4666. Available under: doi: 10.1006/cyto.2000.0752

BibTex

@article{Hartung2000Blood-8305,
  year={2000},
  doi={10.1006/cyto.2000.0752},
  title={Blood cytokine response of low-dose molgramostim (rhGM-CSF)-treated patients},
  number={10},
  volume={12},
  issn={1043-4666},
  journal={Cytokine},
  pages={1570--1574},
  author={Hartung, Thomas and Aulock, Sonja von and Freitag, Marcus and Höxtermann, Stefan and Stücker, Markus and Hoffmann, Klaus and Altmeyer, Peter and Kottke, Andrea and Wendel, Albrecht}
}

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Bibliography of Konstanz

Yes