FAK integrates growth-factor and integrin signals to promote cell migration

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SIEG, David J., Christof R. HAUCK, Du ko ILIĆ, Candice K. KLINGBEIL, Erik SCHAEFER, Caroline H. DAMSKY, David D. SCHLAEPFER, 2000. FAK integrates growth-factor and integrin signals to promote cell migration. In: Nature Cell Biology. 2(5), pp. 249-257. ISSN 1465-7392

@article{Sieg2000integ-8279, title={FAK integrates growth-factor and integrin signals to promote cell migration}, year={2000}, doi={10.1038/35010517}, number={5}, volume={2}, issn={1465-7392}, journal={Nature Cell Biology}, pages={249--257}, author={Sieg, David J. and Hauck, Christof R. and Ilić, Du ko and Klingbeil, Candice K. and Schaefer, Erik and Damsky, Caroline H. and Schlaepfer, David D.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8279"> <dc:contributor>Damsky, Caroline H.</dc:contributor> <dc:creator>Schlaepfer, David D.</dc:creator> <dc:contributor>Hauck, Christof R.</dc:contributor> <dcterms:abstract xml:lang="eng">Here we show that cells lacking focal adhesion kinase (FAK) are refractory to motility signals from platelet-derived and epidermal growth factors (PDGF and EGF respectively), and that stable re-expression of FAK rescues these defects. FAK associates with activated PDGF- and EGF-receptor (PDGFR and EGFR) signalling complexes, and expression of the band-4.1-like domain at the FAK amino terminus is sufficient to mediate an interaction with activated EGFR. However, efficient EGF-stimulated cell migration also requires FAK to be targeted, by its carboxy-terminal domain, to sites of integrin-receptor clustering. Although the kinase activity of FAK is not needed to promote PDGF- or EGF-stimulated cell motility, kinase-inactive FAK is transphosphorylated at the indispensable Src-kinase-binding site, FAK Y397, after EGF stimulation of cells. Our results establish that FAK is an important receptor-proximal link between growth-factor-receptor and integrin signalling pathways.</dcterms:abstract> <dc:creator>Damsky, Caroline H.</dc:creator> <dcterms:title>FAK integrates growth-factor and integrin signals to promote cell migration</dcterms:title> <dc:rights>deposit-license</dc:rights> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:format>application/pdf</dc:format> <dc:creator>Schaefer, Erik</dc:creator> <dc:contributor>Ilić, Du ko</dc:contributor> <dcterms:bibliographicCitation>First publ. in: Nature Cell Biology 2 (2000), pp. 249-257</dcterms:bibliographicCitation> <dc:contributor>Sieg, David J.</dc:contributor> <dc:creator>Klingbeil, Candice K.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:42:22Z</dcterms:available> <dc:creator>Hauck, Christof R.</dc:creator> <dc:language>eng</dc:language> <dc:creator>Sieg, David J.</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8279"/> <dc:creator>Ilić, Du ko</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:42:22Z</dc:date> <dc:contributor>Schaefer, Erik</dc:contributor> <dc:contributor>Klingbeil, Candice K.</dc:contributor> <dcterms:issued>2000</dcterms:issued> <dc:contributor>Schlaepfer, David D.</dc:contributor> </rdf:Description> </rdf:RDF>

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