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Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae

Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae

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HAUCK, Christof R., Heike GRASSMÉ, Jörg BOCK, Verena JENDROSSEK, Klaus FERLINZ, Thomas F. MEYER, Erich GULBINS, 2000. Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae. In: FEBS Letters. 478(3), pp. 260-266. ISSN 0014-5793. eISSN 1873-3468

@article{Hauck2000sphin-8267, title={Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae}, year={2000}, number={3}, volume={478}, issn={0014-5793}, journal={FEBS Letters}, pages={260--266}, author={Hauck, Christof R. and Grassmé, Heike and Bock, Jörg and Jendrossek, Verena and Ferlinz, Klaus and Meyer, Thomas F. and Gulbins, Erich} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8267"> <dcterms:abstract xml:lang="eng">The interaction with human phagocytes is a hallmark of symptomatic Neisseria gonorrhoeae infections. Gonococcal outer membrane proteins of the Opa family induce the opsoninindependent uptake of the bacteria that relies on CEACAM receptors and an active signaling machinery of the phagocyte. Here, we show that CEACAM receptor-mediated phagocytosis of Opa52-expressing N. gonorrhoeae into human cells results in a rapid activation of the acid sphingomyelinase. Inhibition of this enzyme by imipramine or SR33557 abolishes opsonin-independent internalization without affecting bacterial adherence. Reconstitution of ceramide, the product of acid sphingomyelinase activity, in imipramine- or SR33557-treated cells restores internalization of the bacteria. Furthermore, we demonstrate that CEACAM receptor-initiated stimulation of other signalling molecules, in particular Src-like tyrosine kinases and Jun Nterminal kinases, requires acid sphingomyelinase. These studies provide evidence for a crucial role of the acid sphingomyelinase for CEACAM receptor-initiated signalling events and internalization of Opa52-expressing N. gonorrhoeae into human neutrophils.</dcterms:abstract> <dc:contributor>Gulbins, Erich</dc:contributor> <dc:contributor>Grassmé, Heike</dc:contributor> <dc:creator>Hauck, Christof R.</dc:creator> <dcterms:title>Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae</dcterms:title> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8267"/> <dc:creator>Gulbins, Erich</dc:creator> <dc:creator>Grassmé, Heike</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:42:17Z</dc:date> <dc:creator>Meyer, Thomas F.</dc:creator> <dc:contributor>Ferlinz, Klaus</dc:contributor> <dc:contributor>Bock, Jörg</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Bock, Jörg</dc:creator> <dc:creator>Jendrossek, Verena</dc:creator> <dc:contributor>Meyer, Thomas F.</dc:contributor> <dc:rights>deposit-license</dc:rights> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:42:17Z</dcterms:available> <dc:contributor>Hauck, Christof R.</dc:contributor> <dcterms:issued>2000</dcterms:issued> <dcterms:bibliographicCitation>First publ. in: FEBS Letters 478 (2000), pp. 260-266</dcterms:bibliographicCitation> <dc:contributor>Jendrossek, Verena</dc:contributor> <dc:format>application/pdf</dc:format> <dc:creator>Ferlinz, Klaus</dc:creator> </rdf:Description> </rdf:RDF>

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