Structure/function relationships of lipoteichoic acids


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MORATH, Siegfried, Sonja von AULOCK, Thomas HARTUNG, 2005. Structure/function relationships of lipoteichoic acids. In: Journal of Endotoxin Research. 11(6), pp. 348-356. ISSN 0968-0519

@article{Morath2005Struc-8263, title={Structure/function relationships of lipoteichoic acids}, year={2005}, doi={10.1177/09680519050110061001}, number={6}, volume={11}, issn={0968-0519}, journal={Journal of Endotoxin Research}, pages={348--356}, author={Morath, Siegfried and Aulock, Sonja von and Hartung, Thomas} }

<rdf:RDF xmlns:rdf="" xmlns:bibo="" xmlns:dc="" xmlns:dcterms="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:abstract xml:lang="eng">The role of lipoteichoic acids (LTAs) from Gram-positive bacteria as immunostimulatory molecules was controversial for many years, as inadequate preparation methods as well as heterogeneous and endotoxin-contaminated commercial preparations led to conflicting results. An improved purification methodology for LTA now yields potent bioactive and chemically defined material, which is currently being characterized in various models. A synthetic analogue of Staphylococcus aureus LTA has proven the structure/function relationship. The key role of D-alanine esters for the immune response of LTA was confirmed by synthetic derivatives. The glycolipid anchor of LTA plays a central role analogous to the lipid A of LPS. Methodological aspects and criteria for quality assessment of LTA preparations are discussed.</dcterms:abstract> <dc:contributor>Morath, Siegfried</dc:contributor> <dcterms:issued>2005</dcterms:issued> <dcterms:title>Structure/function relationships of lipoteichoic acids</dcterms:title> <bibo:uri rdf:resource=""/> <dcterms:available rdf:datatype="">2011-03-24T17:42:15Z</dcterms:available> <dc:creator>Aulock, Sonja von</dc:creator> <dcterms:rights rdf:resource=""/> <dc:contributor>Aulock, Sonja von</dc:contributor> <dc:rights>deposit-license</dc:rights> <dcterms:bibliographicCitation>First publ. in: Journal of Endotoxin Research 11 (2005), 6, pp. 348-356</dcterms:bibliographicCitation> <dc:creator>Morath, Siegfried</dc:creator> <dc:contributor>Hartung, Thomas</dc:contributor> <dc:date rdf:datatype="">2011-03-24T17:42:15Z</dc:date> <dc:creator>Hartung, Thomas</dc:creator> <dc:format>application/pdf</dc:format> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>

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