Scaffolding microdomains and beyond : the function of reggie/flotillin proteins


Dateien zu dieser Ressource

Prüfsumme: MD5:c10ddf5331b4d1c94d48baef55b7caba

LANGHORST, Matthias F., Alexander REUTER, Claudia STÜRMER, 2005. Scaffolding microdomains and beyond : the function of reggie/flotillin proteins. In: Cellular and Molecular Life Science. 62(19-20), pp. 2228-2240. ISSN 1420-682X. eISSN 1420-9071. Available under: doi: 10.1007/s00018-005-5166-4

@article{Langhorst2005Scaff-8256, title={Scaffolding microdomains and beyond : the function of reggie/flotillin proteins}, year={2005}, doi={10.1007/s00018-005-5166-4}, number={19-20}, volume={62}, issn={1420-682X}, journal={Cellular and Molecular Life Science}, pages={2228--2240}, author={Langhorst, Matthias F. and Reuter, Alexander and Stürmer, Claudia} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dspace:hasBitstream rdf:resource=""/> <bibo:uri rdf:resource=""/> <dspace:isPartOfCollection rdf:resource=""/> <dc:contributor>Stürmer, Claudia</dc:contributor> <dc:creator>Stürmer, Claudia</dc:creator> <dc:format>application/pdf</dc:format> <dc:rights>terms-of-use</dc:rights> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Langhorst, Matthias F.</dc:contributor> <dcterms:title>Scaffolding microdomains and beyond : the function of reggie/flotillin proteins</dcterms:title> <dcterms:isPartOf rdf:resource=""/> <dcterms:rights rdf:resource=""/> <dc:contributor>Reuter, Alexander</dc:contributor> <dc:creator>Reuter, Alexander</dc:creator> <dcterms:issued>2005</dcterms:issued> <dc:language>eng</dc:language> <dcterms:bibliographicCitation>First publ. in: Cellular and Molecular Life Science 62 (2005), pp. 2228-2240</dcterms:bibliographicCitation> <dcterms:available rdf:datatype="">2011-03-24T17:42:11Z</dcterms:available> <dc:date rdf:datatype="">2011-03-24T17:42:11Z</dc:date> <dc:creator>Langhorst, Matthias F.</dc:creator> <dcterms:abstract xml:lang="eng">Reggie/flotillin proteins are considered to be components of lipid rafts and are commonly used as marker proteins for lipid microdomains. Yet almost a decade after their discovery, the function of reggies/flotillins is still enigmatic. In this review we summarize the present state of knowledge on reggie/flotillin structure, localization and function, and discuss the role of the proteins in development and disease. Based on insights into reggie/flotillin function and by comparison with related proteins of the so-called SPFH (Stomatin/Prohibitin/Flotillin/HflK/C) protein family, including stomatin, podocin and prohibitin, we propose the existence of specific types of protein-defined microdomains which are sculpt by the clustering of individual SPFH proteins. As "specialized rafts" similar to caveolae, these membrane domains provide platforms for the recruitment of multiprotein complexes. Since, under certain circumstances, reggie-2/flotillin-1 translocates to the nucleus, reggie/flotillin microdomains are not only stable scaffolds but also dynamic units with their own regulatory functions.</dcterms:abstract> <dcterms:hasPart rdf:resource=""/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

115_Scaffolding_microdomains_and_beyond.pdf 238

Das Dokument erscheint in:

terms-of-use Solange nicht anders angezeigt, wird die Lizenz wie folgt beschrieben: terms-of-use

KOPS Suche


Mein Benutzerkonto