KOPS - Das Institutionelle Repositorium der Universität Konstanz

Opa Proteins of Pathogenic Neisseriae Initiate Src Kinase-Dependent or Lipid Raft-Mediated Uptake via Distinct Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule Isoforms

Opa Proteins of Pathogenic Neisseriae Initiate Src Kinase-Dependent or Lipid Raft-Mediated Uptake via Distinct Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule Isoforms

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:1d473027c5f8166cd9c7f61e6868c419

SCHMITTER, Tim, Stefan PILS, Stephanie WEIBEL, Franziska AGERER, Lisa PETERSON, Alexander BUNTRU, Kathrin KOPP, Christof R. HAUCK, 2007. Opa Proteins of Pathogenic Neisseriae Initiate Src Kinase-Dependent or Lipid Raft-Mediated Uptake via Distinct Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule Isoforms. In: Infection and Immunity. 75(8), pp. 4116-4126. ISSN 0019-9567

@article{Schmitter2007Prote-8181, title={Opa Proteins of Pathogenic Neisseriae Initiate Src Kinase-Dependent or Lipid Raft-Mediated Uptake via Distinct Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule Isoforms}, year={2007}, doi={10.1128/IAI.01835-06}, number={8}, volume={75}, issn={0019-9567}, journal={Infection and Immunity}, pages={4116--4126}, author={Schmitter, Tim and Pils, Stefan and Weibel, Stephanie and Agerer, Franziska and Peterson, Lisa and Buntru, Alexander and Kopp, Kathrin and Hauck, Christof R.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8181"> <dc:format>application/pdf</dc:format> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:41:13Z</dc:date> <dc:language>eng</dc:language> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:41:13Z</dcterms:available> <dc:creator>Weibel, Stephanie</dc:creator> <dc:creator>Peterson, Lisa</dc:creator> <dc:creator>Agerer, Franziska</dc:creator> <dc:contributor>Schmitter, Tim</dc:contributor> <dc:creator>Hauck, Christof R.</dc:creator> <dc:rights>deposit-license</dc:rights> <dc:contributor>Pils, Stefan</dc:contributor> <dcterms:bibliographicCitation>First publ. in: Infection and Immunity 75 (2007), 8, pp. 4116 4126</dcterms:bibliographicCitation> <dcterms:abstract xml:lang="eng">Several pathogenic bacteria exploit human carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) for adhesion to and invasion into their host cells. CEACAM isoforms have characteristic expression patterns on epithelial, endothelial, or hematopoietic cells, providing bacteria with distinct sets of receptors on particular tissues. For example, while CEACAM1 and CEACAM6 have a wide tissue distribution, CEACAM3, CEACAM4, and CEACAM8 are uniquely expressed on primary human granulocytes, whereas CEA and CEACAM7 are limited to epithelia. By reconstitution of a CEACAM-deficient cell line with individual CEACAMs, we have analyzed the requirements for CEACAM-mediated internalization of Neisseria gonorrhoeae. Our results point to two mechanistically different uptake pathways triggered by either epithelial CEACAMs (CEACAM1, CEA, and CEACAM6) or the granulocyte-specific CEACAM3. In particular, CEACAM3-mediated uptake critically depends on Src family protein tyrosine kinase (PTK) activity, and CEACAM3 associates with the SH2 domains of several Src PTKs. In contrast, epithelial CEACAMs require the integrity of cholesterol-rich membrane microdomains and are affected by cholesterol depletion, whereas CEACAM3-mediated uptake by transfected cells or the opsonin-independent phagocytosis by human granulocytes is not altered in the presence of cholesterol chelators. These results allow the subdivision of all human CEACAMs known to be utilized as pathogen receptors into functional groups and point to important consequences for bacterial engagement of distinct CEACAM isoforms.</dcterms:abstract> <dc:creator>Schmitter, Tim</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8181"/> <dc:creator>Pils, Stefan</dc:creator> <dcterms:title>Opa Proteins of Pathogenic Neisseriae Initiate Src Kinase-Dependent or Lipid Raft-Mediated Uptake via Distinct Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule Isoforms</dcterms:title> <dcterms:issued>2007</dcterms:issued> <dc:contributor>Buntru, Alexander</dc:contributor> <dc:contributor>Kopp, Kathrin</dc:contributor> <dc:creator>Buntru, Alexander</dc:creator> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:contributor>Weibel, Stephanie</dc:contributor> <dc:contributor>Peterson, Lisa</dc:contributor> <dc:contributor>Hauck, Christof R.</dc:contributor> <dc:creator>Kopp, Kathrin</dc:creator> <dc:contributor>Agerer, Franziska</dc:contributor> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

2007_Schmitter_et_al_InfectImmun.pdf 152

Das Dokument erscheint in:

deposit-license Solange nicht anders angezeigt, wird die Lizenz wie folgt beschrieben: deposit-license

KOPS Suche


Stöbern

Mein Benutzerkonto