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Modulation of the Inhibitory Substrate Properties of Oligodendrocytes by Platelet-Derived Growth Factor

Modulation of the Inhibitory Substrate Properties of Oligodendrocytes by Platelet-Derived Growth Factor

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LANG, Dirk M., Michael HILLE, Martin E. SCHWAB, Claudia STÜRMER, 1996. Modulation of the Inhibitory Substrate Properties of Oligodendrocytes by Platelet-Derived Growth Factor. In: The Journal of Neuroscience. 16(18), pp. 5741-5748

@article{Lang1996Modul-8178, title={Modulation of the Inhibitory Substrate Properties of Oligodendrocytes by Platelet-Derived Growth Factor}, year={1996}, number={18}, volume={16}, journal={The Journal of Neuroscience}, pages={5741--5748}, author={Lang, Dirk M. and Hille, Michael and Schwab, Martin E. and Stürmer, Claudia} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8178"> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:41:11Z</dcterms:available> <dc:creator>Hille, Michael</dc:creator> <dc:contributor>Stürmer, Claudia</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8178"/> <dcterms:bibliographicCitation>First publ. in: The Journal of Neuroscience 16 (1996), 18, pp. 5741-5748</dcterms:bibliographicCitation> <dc:contributor>Lang, Dirk M.</dc:contributor> <dc:creator>Schwab, Martin E.</dc:creator> <dcterms:title>Modulation of the Inhibitory Substrate Properties of Oligodendrocytes by Platelet-Derived Growth Factor</dcterms:title> <dcterms:issued>1996</dcterms:issued> <dc:format>application/pdf</dc:format> <dc:creator>Stürmer, Claudia</dc:creator> <dc:contributor>Schwab, Martin E.</dc:contributor> <dc:language>eng</dc:language> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dcterms:abstract xml:lang="eng">Although growth cones typically collapse after encountering O1/galactocerebroside (GalC)-positive oligodendrocytes, the majority of growth cones traversed oligodendrocytes, which were raised for 8-10 d in medium containing 10 ng/ml platelet-derived growth factor (PDGF). Oligodendrocytes raised 8-10 d in control medium caused growth cone collapse as they normally do, but failed to elicit this response after being transferred to PDGF-containing medium for an additional 8-10 d. The opposite was observed when PDGF-treated oligodendrocytes were brought to control medium. Growth cones collapsed when contacting these cells. Oligodendrocytes also lost their collapse-inducing activity when raised in medium conditioned by astrocytes, known to produce PDGF. Antibody IN-1 is directed against neurite growth inhibitors (NI), proteins of 35 and 250 kDa on the surface of O1/GalC-positive oligodendrocytes, which are known to elicit growth cone collapse. IN-1 immunoreactivity was markedly reduced in PDGF-treated oligodendrocytes. However, both PDGF-treated and control oligodendrocytes exhibited myelin-associated glycoprotein, proteolipid protein, and myelin basic protein immunoreactivity. This suggests that PDGF-treatment affects NI expression but does not interfere with the expression of advanced myelin marker proteins. Because NI cause growth cone collapse, the loss of collapse-inducing activity by PDGF-treated oligodendrocytes suggests that PDGF regulates, directly or indirectly, the expression of these proteins.</dcterms:abstract> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:41:11Z</dc:date> <dc:creator>Lang, Dirk M.</dc:creator> <dc:contributor>Hille, Michael</dc:contributor> <dc:rights>deposit-license</dc:rights> </rdf:Description> </rdf:RDF>

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