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The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin

The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin

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WANG, Xiaoyang, Changlian ZHU, Xinhua WANG, Jens Gammeltoft GERWIEN, André SCHRATTENHOLZ, Mats SANDBERG, Marcel LEIST, Klas BLOMGREN, 2004. The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin. In: Journal of Neurochemistry. 91(4), pp. 900-910. ISSN 0022-3042. eISSN 1471-4159

@article{Wang2004noner-8136, title={The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin}, year={2004}, doi={10.1111/j.1471-4159.2004.02769.x}, number={4}, volume={91}, issn={0022-3042}, journal={Journal of Neurochemistry}, pages={900--910}, author={Wang, Xiaoyang and Zhu, Changlian and Wang, Xinhua and Gerwien, Jens Gammeltoft and Schrattenholz, André and Sandberg, Mats and Leist, Marcel and Blomgren, Klas} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8136"> <dc:format>application/pdf</dc:format> <dc:creator>Wang, Xiaoyang</dc:creator> <dc:language>eng</dc:language> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:contributor>Wang, Xiaoyang</dc:contributor> <dc:contributor>Leist, Marcel</dc:contributor> <dc:contributor>Schrattenholz, André</dc:contributor> <dc:contributor>Sandberg, Mats</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8136"/> <dcterms:bibliographicCitation>First publ. in: Journal of Neurochemistry 91 (2004), pp. 900-910</dcterms:bibliographicCitation> <dcterms:abstract xml:lang="eng">Recently, erythropoietin (EPO) and the nonerythropoietic derivative asialoEPO have been linked to tissue protection in the nervous system. In this study, we tested their effects in a model of neonatal hypoxia-ischemia (HI) in 7-day-old rats (unilateral carotid ligation and exposure to 7.7% O2 for 50 min). EPO (10 U/g body weight ¼ 80 ng/g; n ¼ 24), asialoEPO (80 ng/g; n ¼ 23) or vehicle (phosphate-buffered saline with 0.1% human serum albumin; n ¼ 24) was injected intraperitoneally 4 h before HI. Both drugs were protective, as judged by measuring the infarct volumes, neuropathological score and gross morphological score. The infarct volumes were significantly reduced by both EPO (52%) and asialoEPO (55%) treatment, even though the plasma levels of asialoEPO had dropped below the detection limit (1 pM) at the onset of HI, while those of EPO were in the nanomolar range. Thus, a brief trigger by asialoEPO before the insult appears to be sufficient for protection. Proteomics analysis after asialoEPO treatment alone (no HI) revealed at least one differentially up-regulated protein, synaptosome-associated protein of 25 kDa (SNAP- 25). Activation (phosphorylation) of ERK was significantly reduced in asialoEPO-treated animals after HI. EPO and the nonerythropoietic asialoEPO both provided significant and equal neuroprotection when administered 4 h prior to HI in 7-day-old rats. The protection might be related to reduced ERK activation and up-regulation of SNAP-25.</dcterms:abstract> <dcterms:issued>2004</dcterms:issued> <dcterms:title>The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin</dcterms:title> <dc:contributor>Gerwien, Jens Gammeltoft</dc:contributor> <dc:contributor>Zhu, Changlian</dc:contributor> <dc:contributor>Blomgren, Klas</dc:contributor> <dc:creator>Wang, Xinhua</dc:creator> <dc:creator>Schrattenholz, André</dc:creator> <dc:creator>Zhu, Changlian</dc:creator> <dc:creator>Blomgren, Klas</dc:creator> <dc:creator>Sandberg, Mats</dc:creator> <dc:creator>Gerwien, Jens Gammeltoft</dc:creator> <dc:contributor>Wang, Xinhua</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:40:53Z</dc:date> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:40:53Z</dcterms:available> <dc:creator>Leist, Marcel</dc:creator> <dc:rights>deposit-license</dc:rights> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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