Differentiation Between Apoptotic and Necrotic Cell Death by Means of the BM Cell Death Detection ELISA or Annexin V Staining

Leist, Marcel; Kühnle, Simone; Single, Barbara; Nicotera, Pierluigi

Differentiation Between Apoptotic and Necrotic Cell Death by Means of the BM Cell Death Detection ELISA or Annexin V Staining

Dateien

Leist_M_Biochemica_1998.pdfGröße: 2.88 MBDownloads: 346

Datum

1998

Autor:innen

Leist, Marcel

Kühnle, Simone

Single, Barbara

Nicotera, Pierluigi

URI (zitierfähiger Link)

http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-82664

Link zur Lizenz

Urheberrechtlich geschützt

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Biochemica. 1998, 2, pp. 25-28

Zusammenfassung

Apoptosis and necrosis are two forms of cell death that have been defined on the basis of distinguishable morphological criteria. However, these different types of cell death may involve several common signalling and execution mechanisms. Since various stimuli induce both apoptotic and necrotic death, the mode of cell demise seems to be dependent on intracellular factors. One of these factors is the concentration of ATP. By modulating ATP levels, apoptosis or necrosis can be triggered selectively under otherwise identical conditions. By controlling ATP levels in staurosporine treated Jurkat cells, apoptotic (but not necrotic) cell death was detected selectively, and was quantitated with high sensitivity by the BM Cell Death Detection ELISA or by staining with annexin V.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

apoptosis, cell death detection, annexin staining

Zitieren

ISO 690

LEIST, Marcel, Simone KÜHNLE, Barbara SINGLE, Pierluigi NICOTERA, 1998. Differentiation Between Apoptotic and Necrotic Cell Death by Means of the BM Cell Death Detection ELISA or Annexin V Staining. In: Biochemica. 1998, 2, pp. 25-28

BibTex

@article{Leist1998Diffe-8111,
  year={1998},
  title={Differentiation Between Apoptotic and Necrotic Cell Death by Means of the BM Cell Death Detection ELISA or Annexin V Staining},
  volume={2},
  journal={Biochemica},
  pages={25--28},
  author={Leist, Marcel and Kühnle, Simone and Single, Barbara and Nicotera, Pierluigi}
}

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