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Cellular Trafficking of the Pathogenic Prion Protein PrPSc and Phenotypic Characterisation of Deletion Mutants in the Hydrophobic Domain of the Normal Prion Protein PrPC

Cellular Trafficking of the Pathogenic Prion Protein PrPSc and Phenotypic Characterisation of Deletion Mutants in the Hydrophobic Domain of the Normal Prion Protein PrPC

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Prüfsumme: MD5:1a8fdbe5f925e56a47da954c2d87c42d

VEITH, Nathalie Monika, 2008. Cellular Trafficking of the Pathogenic Prion Protein PrPSc and Phenotypic Characterisation of Deletion Mutants in the Hydrophobic Domain of the Normal Prion Protein PrPC

@phdthesis{Veith2008Cellu-8107, title={Cellular Trafficking of the Pathogenic Prion Protein PrPSc and Phenotypic Characterisation of Deletion Mutants in the Hydrophobic Domain of the Normal Prion Protein PrPC}, year={2008}, author={Veith, Nathalie Monika}, address={Konstanz}, school={Universität Konstanz} }

2011-03-24T17:40:40Z 2008 The localisation of the pathogenic prion protein PrPSc was investigated with light and electron microscopy. The PrPSc specific antibody 15B3 was tested for its efficiency in immuncytochemistry. Subsequently, an appropriate method was found to stain PrPSc selectively. PrPSc was detected in clathrin coated pits, early endosomes, late endosomes/lysosomes nad exosomes. PrPSc could not be observed in lipid droplets.<br />In the next part of the thesis different mutants of the prion protein carrying micro deletions within the hydrophobic region of the prion protein PrPC were investigated. The deletion mutants were checked for their convertibility into PrPSc in scrapie-infected neuroblastoma cells. Veith, Nathalie Monika deposit-license application/pdf Cellular Trafficking of the Pathogenic Prion Protein PrPSc and Phenotypic Characterisation of Deletion Mutants in the Hydrophobic Domain of the Normal Prion Protein PrPC Veith, Nathalie Monika deu 2011-03-24T17:40:40Z

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Diss_Nathalie_Veith.pdf 387

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