Molecular and crystal structure of an amphiphile : 4'-propoxybiphenyl-4-methyl-N,N-dimethylamineoxide dihydrate
Molecular and crystal structure of an amphiphile : 4'-propoxybiphenyl-4-methyl-N,N-dimethylamineoxide dihydrate
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1995
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Biochimica et Biophysica Acta - Biomembranes ; 1234 (1995), 2. - pp. 244-248. - ISSN 0005-2736
Abstract
A novel amphiphile, 4'-propoxybiphenyl-4-methyl-N,N-dimethylamineoxide, has been synthesized, crystallized (P21/a, a = 9.084 Å, b = 8.911 Å, c = 22.460 Å, β=96.224 °) and its crystal structure was determined. The amphiphile forms a bilayer in which the amineoxide oxygen of each molecule binds two water molecules. In the hydrophobic part of the bilayer the biphenyls form edge-to-face contacts, in the polar layer there is a hydrogen bonding network. The potential use of the compound as a detergent for membrane proteins has been demonstrated and the relevance of the amineoxide hydrate for other detergents discussed.
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570 Biosciences, Biology
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Amphiphile,Membrane protein,X-ray crystallography
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DIEDERICHS, Kay, Wolfram WELTE, Jürgen HAUK, Werner KREUTZ, Thomas WACKER, 1995. Molecular and crystal structure of an amphiphile : 4'-propoxybiphenyl-4-methyl-N,N-dimethylamineoxide dihydrate. In: Biochimica et Biophysica Acta - Biomembranes. 1234(2), pp. 244-248. ISSN 0005-2736. Available under: doi: 10.1016/0005-2736(94)00294-YBibTex
@article{Diederichs1995Molec-8077, year={1995}, doi={10.1016/0005-2736(94)00294-Y}, title={Molecular and crystal structure of an amphiphile : 4'-propoxybiphenyl-4-methyl-N,N-dimethylamineoxide dihydrate}, number={2}, volume={1234}, issn={0005-2736}, journal={Biochimica et Biophysica Acta - Biomembranes}, pages={244--248}, author={Diederichs, Kay and Welte, Wolfram and Hauk, Jürgen and Kreutz, Werner and Wacker, Thomas} }
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