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Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB

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KUMAR, Aseem, Yi-Li YANG, Vincenzo FLATI, Sandy DER, Suzanne KADEREIT, Amitabha DEB, Jaharul HAQUE, Luiz REIS, Charles WEISSMANN, Bryan R. G. WILLIAMS, 1997. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB. In: EMBO Journal. 16(2), pp. 406-416. ISSN 0261-4189. eISSN 1460-2075

@article{Kumar1997Defic-8063, title={Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB}, year={1997}, doi={10.1093/emboj/16.2.406}, number={2}, volume={16}, issn={0261-4189}, journal={EMBO Journal}, pages={406--416}, author={Kumar, Aseem and Yang, Yi-Li and Flati, Vincenzo and Der, Sandy and Kadereit, Suzanne and Deb, Amitabha and Haque, Jaharul and Reis, Luiz and Weissmann, Charles and Williams, Bryan R. G.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8063"> <dcterms:bibliographicCitation>First publ. in: EMBO Journal 16 (1997), 2, pp.406 416</dcterms:bibliographicCitation> <dc:language>eng</dc:language> <dc:contributor>Williams, Bryan R. G.</dc:contributor> <dc:creator>Haque, Jaharul</dc:creator> <dcterms:title>Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB</dcterms:title> <dc:creator>Yang, Yi-Li</dc:creator> <dc:creator>Der, Sandy</dc:creator> <dc:creator>Weissmann, Charles</dc:creator> <dc:creator>Deb, Amitabha</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:contributor>Kumar, Aseem</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:39:39Z</dcterms:available> <dc:contributor>Deb, Amitabha</dc:contributor> <dc:creator>Flati, Vincenzo</dc:creator> <dc:contributor>Flati, Vincenzo</dc:contributor> <dc:contributor>Weissmann, Charles</dc:contributor> <dc:contributor>Kadereit, Suzanne</dc:contributor> <dcterms:issued>1997</dcterms:issued> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:39:39Z</dc:date> <dc:creator>Kadereit, Suzanne</dc:creator> <dc:contributor>Der, Sandy</dc:contributor> <dc:rights>deposit-license</dc:rights> <dc:contributor>Yang, Yi-Li</dc:contributor> <dc:creator>Williams, Bryan R. G.</dc:creator> <dc:creator>Kumar, Aseem</dc:creator> <dcterms:abstract xml:lang="eng">The interferon (IFN)-induced double-stranded RNA (dsRNA)-activated Ser/Thr protein kinase (PKR) plays a role in the antiviral and antiproliferative effects of IFN. PKR phosphorylates initiation factor eIF2alpha, thereby inhibiting protein synthesis, and also activates the transcription factor, nuclear factor-kappaB (NF-kappaB), by phosphorylating the inhibitor of NF-kappaB, IkappaB. Mice devoid of functional PKR (Pkr(o/o)) derived by targeted gene disruption exhibit a diminished response to IFN-gamma and poly(rI:rC) (pIC). In embryo fibroblasts derived from Pkr(o/o) mice, interferon regulatory factor 1 (IRF-1) or guanylate binding protein (Gbp) promoter-reporter constructs were unresponsive to IFN-gamma or pIC but response could be restored by co-transfection with PKR. The lack of responsiveness could be attributed to a diminished activation of IRF-1 and/or NF-kappaB in response to IFN-gamma or pIC. Thus, PKR acts as a signal transducer for IFN-stimulated genes dependent on the transcription factors IRF-1 and NF-kappaB.</dcterms:abstract> <dc:contributor>Haque, Jaharul</dc:contributor> <dc:format>application/pdf</dc:format> <dc:contributor>Reis, Luiz</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8063"/> <dc:creator>Reis, Luiz</dc:creator> </rdf:Description> </rdf:RDF>

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