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In vitro investigation of individual and combined cytotoxic effects of ochratoxin A and other selected mycotoxins on renal cells

In vitro investigation of individual and combined cytotoxic effects of ochratoxin A and other selected mycotoxins on renal cells

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HEUSSNER, Alexandra H., Daniel R. DIETRICH, Evelyn O'BRIEN, 2006. In vitro investigation of individual and combined cytotoxic effects of ochratoxin A and other selected mycotoxins on renal cells. In: Toxicology in vitro. 20(3), pp. 332-341. ISSN 0887-2333. Available under: doi: 10.1016/j.tiv.2005.08.003

@article{Heussner2006vitro-8051, title={In vitro investigation of individual and combined cytotoxic effects of ochratoxin A and other selected mycotoxins on renal cells}, year={2006}, doi={10.1016/j.tiv.2005.08.003}, number={3}, volume={20}, issn={0887-2333}, journal={Toxicology in vitro}, pages={332--341}, author={Heussner, Alexandra H. and Dietrich, Daniel R. and O'Brien, Evelyn} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8051"> <dc:creator>Heussner, Alexandra H.</dc:creator> <dc:language>eng</dc:language> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>O'Brien, Evelyn</dc:contributor> <dc:rights>terms-of-use</dc:rights> <dc:creator>O'Brien, Evelyn</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8051"/> <dc:creator>Dietrich, Daniel R.</dc:creator> <dc:contributor>Dietrich, Daniel R.</dc:contributor> <dcterms:issued>2006</dcterms:issued> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:39:32Z</dcterms:available> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:bibliographicCitation>First publ. in: Toxicology in vitro 20 (2006), 3, pp. 332-341</dcterms:bibliographicCitation> <dc:contributor>Heussner, Alexandra H.</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8051/1/In_vitro_investigation_of_individual_and_combined_cytotoxic_effects_of_ochratoxin_A_and_other_selected_mycotoxins_on_renal_cells.pdf"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:39:32Z</dc:date> <dcterms:title>In vitro investigation of individual and combined cytotoxic effects of ochratoxin A and other selected mycotoxins on renal cells</dcterms:title> <dc:format>application/pdf</dc:format> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8051/1/In_vitro_investigation_of_individual_and_combined_cytotoxic_effects_of_ochratoxin_A_and_other_selected_mycotoxins_on_renal_cells.pdf"/> <dcterms:abstract xml:lang="eng">Hundreds of mycotoxins are known to date and many of them are of great interest with regard to human and animal health since they are detected frequently in plant-derived products. Various mycotoxins may occur simultaneously, depending on the environmental and substrate conditions. Considering this coincident production, it is very likely, that humans and animals are always exposed to mixtures rather than to individual compounds. Therefore, future risk assessments should consider mixture toxicity data. This is particularly true for ochratoxin A (OTA), ochratoxin B (OTB), citrinin (CIT) and occasionally for patulin (PAT) as they are all produced by a number of Penicillium and Aspergillus species. Therefore, these four toxins were chosen to study the interactive effects in vitro, using the well-established porcine renal cell line LLC-PK1 and the MTT reduction test as a cytotoxicity endpoint. By application of a step-wise approach to test combination toxicity, using various full factorial as well as a central composite experimental designs, the interactive (synergistic) cytotoxic effects of the these four toxins were assessed. The results obtained in this study confirm a potential for interactive (synergistic) effects of CIT and OTA and possibly other mycotoxins in cells of renal origin.</dcterms:abstract> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> </rdf:Description> </rdf:RDF>

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