Lysosomes in cell death


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GUICCIARDI, Maria Eugenia, Marcel LEIST, Gregory J. GORES, 2004. Lysosomes in cell death. In: Oncogene. 23(16), pp. 2881-2890. ISSN 0950-9232. eISSN 1476-5594. Available under: doi: 10.1038/sj.onc.1207512

@article{Guicciardi2004Lysos-8037, title={Lysosomes in cell death}, year={2004}, doi={10.1038/sj.onc.1207512}, number={16}, volume={23}, issn={0950-9232}, journal={Oncogene}, pages={2881--2890}, author={Guicciardi, Maria Eugenia and Leist, Marcel and Gores, Gregory J.} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:creator>Leist, Marcel</dc:creator> <dcterms:bibliographicCitation>First publ. in: Oncogene 23 (2004), 16, pp. 2881-2890</dcterms:bibliographicCitation> <dc:creator>Guicciardi, Maria Eugenia</dc:creator> <dcterms:rights rdf:resource=""/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Guicciardi, Maria Eugenia</dc:contributor> <dcterms:title>Lysosomes in cell death</dcterms:title> <dspace:hasBitstream rdf:resource=""/> <dc:creator>Gores, Gregory J.</dc:creator> <dcterms:available rdf:datatype="">2011-03-24T17:39:26Z</dcterms:available> <dc:rights>terms-of-use</dc:rights> <dspace:isPartOfCollection rdf:resource=""/> <dcterms:abstract xml:lang="eng">For many years apoptosis research has focused on caspases and their putative role as sole executioners of programmed cell death. Accumulating information now suggests that lysosomal cathepsins are also pivotally involved in this process, especially in pathological conditions. In particular, the role of lysosomes and lysosomal enzymes in initiation and execution of the apoptotic program has become clear in several models, to the point that the existence of a 'lysosomal pathway of apoptosis' is now generally accepted. This pathway of apoptosis can be activated by death receptors, lipid mediators, and photodamage. Lysosomal proteases can be released from the lysosomes into the cytosol, where they contribute to the apoptotic cascade upstream of mitochondria. This review focuses on the players and the molecular mechanisms involved in the lysosomal pathway of apoptosis as well as on the importance of this pathway in development and pathology.</dcterms:abstract> <dcterms:isPartOf rdf:resource=""/> <bibo:uri rdf:resource=""/> <dc:contributor>Gores, Gregory J.</dc:contributor> <dc:language>eng</dc:language> <dcterms:hasPart rdf:resource=""/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Leist, Marcel</dc:contributor> <dc:format>application/pdf</dc:format> <dc:date rdf:datatype="">2011-03-24T17:39:26Z</dc:date> <dcterms:issued>2004</dcterms:issued> </rdf:Description> </rdf:RDF>

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