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Heme uptake across the outer membrane as revealed by crystal structures of the receptor-hemophore complex

Heme uptake across the outer membrane as revealed by crystal structures of the receptor-hemophore complex

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Prüfsumme: MD5:d43b6d3d390850de82e44c960f21fb53

KRIEG, Stefanie, Frédéric HUCHÉ, Kay DIEDERICHS, Nadia IZADI-PRUNEYRE, Anne LECROISEY, Cécile WANDERSMANN, Philippe DELEPELAIRE, Wolfram WELTE, 2009. Heme uptake across the outer membrane as revealed by crystal structures of the receptor-hemophore complex. In: PNAS. 106(4), pp. 1045-1050. ISSN 0027-8424. eISSN 1091-6490

@article{Krieg2009uptak-8026, title={Heme uptake across the outer membrane as revealed by crystal structures of the receptor-hemophore complex}, year={2009}, doi={10.1073/pnas.0809406106}, number={4}, volume={106}, issn={0027-8424}, journal={PNAS}, pages={1045--1050}, author={Krieg, Stefanie and Huché, Frédéric and Diederichs, Kay and Izadi-Pruneyre, Nadia and Lecroisey, Anne and Wandersmann, Cécile and Delepelaire, Philippe and Welte, Wolfram} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/8026"> <dcterms:abstract xml:lang="eng">Gram-negative bacteria use specific heme uptake systems, relying on outer membrane receptors and excreted heme-binding proteins (hemophores) to scavenge and actively transport heme, To unravel the unknown molecular details involved. we present 3 structures of the Serratia marcescens receptor HasR in complex with its hemophore HasA. The transfer of heme over a distance of 9 A from its high-affinity site in HasA into a site of lower affinity in HasR is coupled with the exergonic complex formation of the 2 proteins. Upon docking to the receptor. 1 of the 2 axial heme coordinations of the hemophore is initially broken. but the position and orientation of the heme is preserved, Subsequently. steric displacement of heme by a receptor residue ruptures the other axial, coordination. leading to heme transfer into the receptor,</dcterms:abstract> <dc:contributor>Delepelaire, Philippe</dc:contributor> <dc:creator>Diederichs, Kay</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:39:22Z</dc:date> <dc:contributor>Lecroisey, Anne</dc:contributor> <dc:rights>deposit-license</dc:rights> <dc:creator>Wandersmann, Cécile</dc:creator> <dc:contributor>Huché, Frédéric</dc:contributor> <dc:creator>Delepelaire, Philippe</dc:creator> <dc:creator>Huché, Frédéric</dc:creator> <dc:contributor>Diederichs, Kay</dc:contributor> <dc:format>application/pdf</dc:format> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8026"/> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:creator>Welte, Wolfram</dc:creator> <dc:creator>Krieg, Stefanie</dc:creator> <dc:contributor>Krieg, Stefanie</dc:contributor> <dc:contributor>Izadi-Pruneyre, Nadia</dc:contributor> <dc:contributor>Welte, Wolfram</dc:contributor> <dcterms:bibliographicCitation>First publ. in: PNAS ; 106 (2009), 4. - S. 1045-1050</dcterms:bibliographicCitation> <dc:language>eng</dc:language> <dc:creator>Izadi-Pruneyre, Nadia</dc:creator> <dc:creator>Lecroisey, Anne</dc:creator> <dcterms:issued>2009</dcterms:issued> <dcterms:title>Heme uptake across the outer membrane as revealed by crystal structures of the receptor-hemophore complex</dcterms:title> <dc:contributor>Wandersmann, Cécile</dc:contributor> </rdf:Description> </rdf:RDF>

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