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Complete Ion-Coordination Structure in the Rotor Ring of Na+ -Dependent F-ATP Synthases

Complete Ion-Coordination Structure in the Rotor Ring of Na+ -Dependent F-ATP Synthases


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MEIER, Thomas, Alexander KRAH, Peter J. BOND, Denys POGORYELOV, Kay DIEDERICHS, José D. FARALDO-GÓMEZ, 2009. Complete Ion-Coordination Structure in the Rotor Ring of Na+ -Dependent F-ATP Synthases. In: Journal of Molecular Biology. 391(2), pp. 498-507. ISSN 0022-2836. eISSN 1089-8638

@article{Meier2009Compl-7963, title={Complete Ion-Coordination Structure in the Rotor Ring of Na+ -Dependent F-ATP Synthases}, year={2009}, doi={10.1016/j.jmb.2009.05.082}, number={2}, volume={391}, issn={0022-2836}, journal={Journal of Molecular Biology}, pages={498--507}, author={Meier, Thomas and Krah, Alexander and Bond, Peter J. and Pogoryelov, Denys and Diederichs, Kay and Faraldo-Gómez, José D.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7963"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:38:54Z</dc:date> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:creator>Meier, Thomas</dc:creator> <dc:contributor>Bond, Peter J.</dc:contributor> <dc:rights>deposit-license</dc:rights> <dcterms:abstract xml:lang="eng">The membrane-embedded rotors of Na(+)-dependent F-ATP synthases comprise 11 c-subunits that form a ring, with 11 Na(+) binding sites in between adjacent subunits. Following an updated crystallographic analysis of the c-ring from Ilyobacter tartaricus, we report the complete ion-coordination structure of the Na(+) sites. In addition to the four residues previously identified, there exists a fifth ligand, namely, a buried structural water molecule. This water is itself coordinated by Thr67, which, sequence analysis reveals, is the only residue involved in binding that distinguishes Na(+) synthases from H(+)-ATP synthases known to date. Molecular dynamics simulations and free-energy calculations of the c-ring in a lipid membrane lend clear support to the notion that this fifth ligand is a water molecule, and illustrate its influence on the selectivity of the binding sites. Given the evolutionary ascendancy of sodium over proton bioenergetics, this structure uncovers an ancient strategy for selective ion coupling in ATP synthases.</dcterms:abstract> <dc:creator>Bond, Peter J.</dc:creator> <dc:creator>Diederichs, Kay</dc:creator> <dcterms:issued>2009</dcterms:issued> <dcterms:bibliographicCitation>First publ. in: Journal of Molecular Biology ; 391 (2009), 2. - S. 498-507</dcterms:bibliographicCitation> <dc:contributor>Faraldo-Gómez, José D.</dc:contributor> <dc:contributor>Krah, Alexander</dc:contributor> <dc:contributor>Diederichs, Kay</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Pogoryelov, Denys</dc:contributor> <dc:format>application/pdf</dc:format> <dcterms:title>Complete Ion-Coordination Structure in the Rotor Ring of Na+ -Dependent F-ATP Synthases</dcterms:title> <dc:creator>Faraldo-Gómez, José D.</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7963"/> <dc:creator>Pogoryelov, Denys</dc:creator> <dc:contributor>Meier, Thomas</dc:contributor> <dc:creator>Krah, Alexander</dc:creator> </rdf:Description> </rdf:RDF>

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