Die Wirkungsweise herbizidaler Chloracetamide

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MATTHES, Bernd, 2001. Die Wirkungsweise herbizidaler Chloracetamide

@phdthesis{Matthes2001Wirku-7958, title={Die Wirkungsweise herbizidaler Chloracetamide}, year={2001}, author={Matthes, Bernd}, address={Konstanz}, school={Universität Konstanz} }

Matthes, Bernd 2011-03-24T17:38:50Z 2011-03-24T17:38:50Z Mode of action of chloroacetamide herbicides 2001 Die Wirkungsweise herbizidaler Chloracetamide Matthes, Bernd deu deposit-license application/pdf This study verifies the significance of very-long-chain fatty acids (VLCFAs), consisting of more than 18 carbon atoms, for the vitality of higher plants. The key enzyme of VLCFA biosynthesis, the extraplastidary fatty acid elongase, is shown for the first time to be the primary target site of chloroacetamide herbicides.<br />With an analysis of the fatty acid composition and the metabolism of 14C-labelled precursors (sterate, malonate, acetate), the reduction of VLCFAs was determined in vivo. The inhibition of the recombinant protein substantiates the first and rate-limiting step of VLCFA biosynthesis, the condensation of acyl-CoA with malonyl-CoA to b-ketoacyl-CoA, to be the primary target site of chloroacetamides (I50 = 10-100 nM).<br />The concentration of VLCFAs within the untreated cell is low, the very-long-chain compounds are found mainly in plasma membrane lipids and epicuticular waxes. A shift of fatty acids towards shorter chain length or even the complete depletion of very-long-chain components is the consequence of the inhibition of VLCFA biosynthesis. Especially the loss of plasma membrane VLCFAs is involved in phytotxic effects of chloroacetamides such as the inhibition of membrane biogenesis and mitosis.

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