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Lesion-Induced Regulation of Netrin Receptors and Modification of Netrin-1 Expression in the Retina of Fish and Grafted Rats

Lesion-Induced Regulation of Netrin Receptors and Modification of Netrin-1 Expression in the Retina of Fish and Grafted Rats

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PETRAUSCH, Barbara, Marion JUNG, Christian A. LEPPERT, Claudia STÜRMER, 2000. Lesion-Induced Regulation of Netrin Receptors and Modification of Netrin-1 Expression in the Retina of Fish and Grafted Rats. In: Molecular and Cellular Neuroscience. 16(4), pp. 350-364. ISSN 1044-7431. Available under: doi: 10.1006/mcne.2000.0877

@article{Petrausch2000Lesio-7908, title={Lesion-Induced Regulation of Netrin Receptors and Modification of Netrin-1 Expression in the Retina of Fish and Grafted Rats}, year={2000}, doi={10.1006/mcne.2000.0877}, number={4}, volume={16}, issn={1044-7431}, journal={Molecular and Cellular Neuroscience}, pages={350--364}, author={Petrausch, Barbara and Jung, Marion and Leppert, Christian A. and Stürmer, Claudia} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7908"> <dc:contributor>Petrausch, Barbara</dc:contributor> <dcterms:issued>2000</dcterms:issued> <dcterms:bibliographicCitation>First publ. in: Molecular and Cellular Neuroscience 16 (2000), 4, pp. 350-364</dcterms:bibliographicCitation> <dcterms:abstract xml:lang="eng">To determine whether netrin receptors (DCC, UNC5H1, UNC5H2) and netrin-1 are present in the adult rat retina and may affect regeneration of retinal ganglion cell (RGC) axons into peripheral nerve (PN) grafts, in situ hybridization (ISH) and immunostaining experiments were performed in normal and operated rats. Netrin-1 expression was not found in the optic nerve head of adult rats, normal and postlesion, but appeared transiently at 7 and 14 days after PN grafting. ISH signals of netrin receptors, however, disappeared from RGCs within 2 days after lesion and remained absent after PN grafting except for UNC5H2, which transiently occurred in a few RGCs. Netrin-1 expression was observed in the optic nerve head of adult fish, normal and postlesion, and the netrin-1 Fc fusion protein bound to young growing and all regenerating axons. Thus, the netrin-1-dependent guidance system continues to function in fish but apparently no longer operates in adult rats.</dcterms:abstract> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7908/1/Lesion_induced_downregulation.pdf"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7908/1/Lesion_induced_downregulation.pdf"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Leppert, Christian A.</dc:creator> <dc:creator>Jung, Marion</dc:creator> <dc:contributor>Leppert, Christian A.</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:title>Lesion-Induced Regulation of Netrin Receptors and Modification of Netrin-1 Expression in the Retina of Fish and Grafted Rats</dcterms:title> <dc:creator>Petrausch, Barbara</dc:creator> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:format>application/pdf</dc:format> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:38:26Z</dc:date> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Jung, Marion</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:38:26Z</dcterms:available> <dc:language>eng</dc:language> <dc:creator>Stürmer, Claudia</dc:creator> <dc:rights>terms-of-use</dc:rights> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7908"/> <dc:contributor>Stürmer, Claudia</dc:contributor> </rdf:Description> </rdf:RDF>

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