KOPS - Das Institutionelle Repositorium der Universität Konstanz

Target recognition and dynamics of axonal growth in the retinotectal system of fish

Target recognition and dynamics of axonal growth in the retinotectal system of fish

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:d8bbe8f1b32cec73bb03050a70d60467

STÜRMER, Claudia, 1990. Target recognition and dynamics of axonal growth in the retinotectal system of fish. In: Neuroscience Research Supplements. 13, pp. S1-S10. ISSN 0921-8696

@article{Sturmer1990Targe-7892, title={Target recognition and dynamics of axonal growth in the retinotectal system of fish}, year={1990}, doi={10.1016/0921-8696(90)90024-W}, volume={13}, issn={0921-8696}, journal={Neuroscience Research Supplements}, pages={S1--S10}, author={Stürmer, Claudia} }

Stürmer, Claudia First publ. in: Neuroscience Research Supplements ; 13 (1990). - S. S1-S10 Embryonic and regenerating retinal axons in fish are able to seek out their retinotopic target sites in the tectum. Neither a specific preordering of axons in the retinotectal pathway nor activity-dependent axon-target interactions are required for appropriate previous axonal targeting. Axon-target recognition appears to be predominantly mediated by positional cell surface markers. The discrimination of position-dependent differences by retinal axons in a special in vitro assay is consistent with this concept.<br />To understand retinal previous axonal regeneration we have analyzed the glial cells of the fish optic nerve and the expression of growth-associated cell surface molecules on the regenerating axons. The surfaces of the glial cells identified as oligodendrocytes are excellent substrates for the elongation of regenerating axons. Raising monoclonal antibodies we have found 3 cell surface proteins specific for growing axons. In the normal adult goldfish optic nerve, these proteins are only expressed by the few new axons from the newborn ganglion cells at the retinal margin. They are re-expressed on all axons during regeneration. A known cell surface molecule, NCAM, is expressed in a similar, specific spatiotemporal pattern on the fish retinal axons and may in normal nerves contribute to the establishment of the age-related fiber association. Whether the re-expression of NCAM and the antigens detected by the novel monoclonal antibodies are functionally involved in previous axonal growth and regeneration remains to be investigated. 1990 Stürmer, Claudia 2011-03-24T17:38:19Z Target recognition and dynamics of axonal growth in the retinotectal system of fish deposit-license application/pdf eng 2011-03-24T17:38:19Z

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Target_recognition_1990.pdf 70

Das Dokument erscheint in:

deposit-license Solange nicht anders angezeigt, wird die Lizenz wie folgt beschrieben: deposit-license

KOPS Suche


Stöbern

Mein Benutzerkonto